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Specificity of the peroxisome proliferation response in mussels exposed to environmental pollutants
Cajaraville, M.P.; Ortiz-Zarragoitia, M. (2006). Specificity of the peroxisome proliferation response in mussels exposed to environmental pollutants. Aquat. Toxicol. 78(Supplement 1): S117-S123. https://dx.doi.org/10.1016/j.aquatox.2006.02.016
In: Aquatic Toxicology. Elsevier Science: Tokyo; New York; London; Amsterdam. ISSN 0166-445X; e-ISSN 1879-1514
Ook verschenen in:Pampanin, D.M.; Anderson, O.K.; Viarengo, A. (Ed.) (2006). The Stavanger Workshop: Biological Effects of Environmental Pollution (BEEP) in marine coastal ecosystem: the Stavanger mesocosm exposure studies. Aquatic Toxicology, Special Issue 78(Suppl. 1). Elsevier: The Netherlands. S1-S128 pp., meer
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| Author keywords |
peroxisome proliferation; mussels; biomarkers; aquatic pollution |
| Auteurs | | Top |
- Cajaraville, M.P.
- Ortiz-Zarragoitia, M.
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| Abstract |
Peroxisome proliferation has been proposed as novel biomarker of exposure to organic pollutants in aquatic organisms. Peroxisome proliferator compounds comprise a heterogeneous group of substances known for their ability to cause massive proliferation of peroxisomes and liver carcinogenesis in sensitive species such as rodents. Recently, several marine organisms (mussels and fish) have been shown as target species of peroxisome proliferators. In the present work, we aimed to investigate the specificity of the peroxisome proliferation response in mussels. For this purpose, mussels (Mytilus edulis) were exposed for three weeks to North Sea crude oil (NSO), a mixture of NSO, alkylphenols and extra PAHs (MIX), diallylphthalate (DAP), bisphenol-A (BPA) and tetrabromodiphenylether (TBDE), or transplanted for three weeks to four stations showing different copper concentrations in a copper mine. Peroxisome proliferation was assessed by measuring the activity of the peroxisomal β-oxidation enzyme acyl-CoA oxidase (AOX) and the volume density occupied by peroxisomes (VVP) in the digestive gland. Mussels exposed to NSO and MIX showed significantly increased AOX activities and VVP compared to control animals. Significantly higher VVP was also found in DAP and TBDE exposed mussels. VVP did not vary in mussels transplanted into a copper concentration gradient. Our results confirm the usefulness and specificity of peroxisome proliferation as a suitable biomarker of exposure to organic contaminants such as oil derived hydrocarbons, phthalate plasticizers and polybrominated flame retardants in mussels. |
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