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| Biotransformation of polychlorinated biphenyls (PCBs) and bioformation of hydroxylated PCBs in fish Buckman, A.H.; Wong, C.S.; Chow, E.A.; Brown, S.B.; Solomon, K.R.; Fisk, A.T. (2006). Biotransformation of polychlorinated biphenyls (PCBs) and bioformation of hydroxylated PCBs in fish. Aquat. Toxicol. 78(2): 176-185. https://dx.doi.org/10.1016/j.aquatox.2006.02.033
In: Aquatic Toxicology. Elsevier Science: Tokyo; New York; London; Amsterdam. ISSN 0166-445X; e-ISSN 1879-1514
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Fishes > Osteichthyes > Salmoniformes > Salmonidae > Salmo > Freshwater fishes > Rainbow trout Metabolites Oncorhynchus mykiss (Walbaum, 1792) [WoRMS] Marien/Kust; Zoet water |
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 80 g) were exposed to dietary concentrations of an environmentally relevant mixture of PCBs. Eight OH-PCBs were found in the plasma of rainbow trout after 30 days of exposure to the PCBs, the relative pattern of which was similar to those observed in wild lake trout (Salvelinus namaycush) from Lake Ontario. Hydroxylated-PCBs were not found (detection limit 0.02 pg/g) in the food or control (not PCB-exposed) fish. A curvilinear log t1/2–log Kow relationship for recalcitrant PCBs was found, similar to previously reported relationships, although t1/2 values were longer and shorter than studies using smaller fish or cooler temperatures, respectively. A number of PCB congeners fell below the log t1/2–log Kow relationship providing the first estimates of non-chiral PCB biotransformation rates in fish. Enantioselective degradation of the chiral congeners PCBs 91 and 136, also indicated biotransformation. Biotransformation of PCBs was structure-dependent with greater biotransformation of PCBs with vicinal hydrogen atoms in the meta/para positions, suggesting CYP 2B-like biotransformation. Other chiral congeners with a meta/para substitution pattern showed no enantioselective degradation but were biotransformed based on the log t1/2–log Kow relationship. The results of this study demonstrate that laboratory held rainbow trout can biotransform a number of PCB congeners and that bioformation is likely an important source of OH-PCBs in wild salmonids of the Great Lakes. |
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