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Protective effects of selenium on mercury-induced DNA damage in mussel haemocytes Tran, D.; Moody, A.J.; Fisher, A.S.; Foulkes, M.E.; Jha, A.N. (2007). Protective effects of selenium on mercury-induced DNA damage in mussel haemocytes. Aquat. Toxicol. 84(1): 11-18. https://dx.doi.org/10.1016/j.aquatox.2007.05.009 In: Aquatic Toxicology. Elsevier Science: Tokyo; New York; London; Amsterdam. ISSN 0166-445X; e-ISSN 1879-1514

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Beschikbaar in	Auteurs
VLIZ: Non-open access 353246 [ aanvragen ]

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Trefwoorden

Chemical elements > Metals > Heavy metals > Mercury Chemical elements > Metals > Heavy metals > Selenium Peptides > Proteins > Enzymes > Oxidoreductases > Peroxidases > Glutathione peroxidase Mytilus edulis Linnaeus, 1758 [WoRMS] Marien/Kust

Author keywords

selenium; mercury; comet assay; glutathione peroxidase; Mytilus edulis

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Auteurs		Top
Tran, D. Moody, A.J. Fisher, A.S.	Foulkes, M.E. Jha, A.N.

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Abstract

Little is known of the antioxidant role of selenium (Se) in aquatic invertebrates. We investigated the effects of Se on mercury-induced DNA damage in haemocytes from Mytilus edulis using alkaline single cell gel electrophoresis, that is, the Comet assay. The basal percentage tail DNA value for mussel haemocytes was 9.8 ± 0.2% (mean ± S.E.M., n = 70). Exposing mussels to Hg2+ (nominal concentration 20 μg L−1) for three days led to an increase in tail DNA to 61.1 ± 1.8% (n = 10). With added Se (as selenite, nominal concentration 4 μg L−1), Hg-induced DNA damage was reduced to 39.5 ± 3.1% (n = 10). Se pre-exposure also provided some protection against Hg-induced DNA damage (% tail DNA = 51.0 ± 2.9%, n = 10). Basal glutathione peroxidase (GPx) activity in cell-free haemolymph was 93.7 ± 3.5 nmol min−1 mg−1 (mean ± S.E.M., n = 70). Increases in GPx activity were seen when Se was added during and/or after exposure to Hg. For example, a 3–4-fold increase was seen after three days exposure to Hg in the presence of added Se. Interestingly GPx activity doubled after three days in the presence of added Se alone, but was unchanged after exposure to HgCl2 alone. These results suggest that the availability of Se in the natural environment could affect the antioxidant status of mussels, and consequently could affect levels of DNA damage.

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