Zoeken
Zoeken kan via de modus 'eenvoudig zoeken' (één veld) of uitgebreid via 'geavanceerd zoeken' (meerdere velden). Zo kan je bv. zoeken op een combinatie van een auteursnaam (auteur), een jaartal (jaar) en een documenttype.
Boekenmand
Nuttige resultaten kan je aanvinken en toevoegen aan een mandje. De inhoud hiervan kan je exporteren of afdrukken (naar bv. PDF).
RSS
Op de hoogte blijven van nieuw toegevoegde publicaties binnen uw interessegebied? Dit kan door een RSS-feed (?) te maken van jouw zoekopdracht.
nieuwe zoekopdracht
Modified absorption of sGNRH-a following rectal and oral delivery to common carp, Cyprinus carpio L.
Mikolajczyk, T.; Roelants, I.; Epler, P.; Ollevier, F.P.; Chyb, J.; Breton, B. (2002). Modified absorption of sGNRH-a following rectal and oral delivery to common carp, Cyprinus carpio L. Aquaculture 203(3-4): 375-388. dx.doi.org/10.1016/S0044-8486(01)00637-8
In: Aquaculture. Elsevier: Amsterdam; London; New York; Oxford; Tokyo. ISSN 0044-8486; e-ISSN 1873-5622
|  |
| Trefwoord |
Cyprinus carpio Linnaeus, 1758 [WoRMS]
|
| Author keywords |
carp; gonadotropin releasing hormone analogue; dopamine antagonist; oral delivery; intestinal absorption enhancement; gonadotropin secretion |
| Auteurs | | Top |
- Mikolajczyk, T.
- Roelants, I.
- Epler, P.
|
- Ollevier, F.P.
- Chyb, J.
- Breton, B.
|
|
| Abstract |
The present study compare oral and rectal delivery routes of a salmonid gonadotropin releasing hormone analogue (sGnRH-a)+dopamine D2-receptor antagonist, pimozide (Pim), with parenteral administration. In addition, the effect of co-administration of absorption enhancers and peptidase inhibitors were evaluated. Responsiveness to the treatments was examined using GtH II release. Ten micrograms sGnRH-a and 5 mg/kg of Pim per kg fish bw were used in different formulations and routes of delivery. A mixed micellular intestinal absorption enhancement formulation, consisting of oleic acid and a polyoxyethylenesorbitan (Tween), strongly augmented GtH II release stimulated by sGnRH-a+Pim. GtH II release following treatment did not differ from that obtained after intraperitoneal injection of these drugs. In comparison with the saline control or with intraperitoneal injection, the oral and rectal administration of sGnRH a+Pim without intestinal absorption enhancement was not effective in stimulating GtH II release. The addition of the enzyme inhibitor, Na2EDTA or chicken egg trypsin inhibitor to this formulation was only moderately effective in increasing circulating GtH II levels. Among different Tweens, preformulated with oleic acid in a mixed micellular absorption enhancer for rectal delivery of sGnRH-a at a dose of 20 µg/kg bw in pimozide pretreated carps, Tween 20 and Tween 40, resulted in the highest systemic GtH II levels. |
IMIS is ontwikkeld en wordt gehost door het VLIZ.
