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Ligands for ionotropic glutamate receptors
Swanson, G.T.; Sakai, R. (2009). Ligands for ionotropic glutamate receptors, in: Fusetani, N. et al. (Ed.) Marine toxins as research tools. Progress in Molecular and Subcellular Biology. Marine Molecular Biotechnology, 46: pp. 123-157. dx.doi.org/10.1007/978-3-540-87895-7_5
In: Fusetani, N.; Kem, W. (Ed.) (2009). Marine toxins as research tools. Progress in Molecular and Subcellular Biology. Marine Molecular Biotechnology, 46. Springer: Berlin. ISBN 978-3-540-87892-6; e-ISBN 978-3-540-87895-7. xiv, 259 pp. https://dx.doi.org/10.1007/978-3-540-87895-7
In: Müller, W.E.G. (Ed.) Progress in Molecular and Subcellular Biology. Marine Molecular Biotechnology. Springer: Berlin. ISSN 1611-6119
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  • Swanson, G.T.
  • Sakai, R.
Abstract
    Marine-derived small molecules and peptides have played a central role in elaborating pharmacological specificities and neuronal functions of mammalian ionotropic glutamate receptors (iGluRs), the primary mediators of excitatory syn-aptic transmission in the central nervous system (CNS). As well, the pathological sequelae elicited by one class of compounds (the kainoids) constitute a widely-used animal model for human mesial temporal lobe epilepsy (mTLE). New and existing molecules could prove useful as lead compounds for the development of therapeutics for neuropathologies that have aberrant glutamatergic signaling as a central component. In this chapter we discuss natural source origins and pharmacological activities of those marine compounds that target ionotropic glutamate receptors.
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