Zoeken
Zoeken kan via de modus 'eenvoudig zoeken' (één veld) of uitgebreid via 'geavanceerd zoeken' (meerdere velden). Zo kan je bv. zoeken op een combinatie van een auteursnaam (auteur), een jaartal (jaar) en een documenttype.
Boekenmand
Nuttige resultaten kan je aanvinken en toevoegen aan een mandje. De inhoud hiervan kan je exporteren of afdrukken (naar bv. PDF).
RSS
Op de hoogte blijven van nieuw toegevoegde publicaties binnen uw interessegebied? Dit kan door een RSS-feed (?) te maken van jouw zoekopdracht.
nieuwe zoekopdracht
Novel pharmacological targets from Indian cone snails
In: Mini-Reviews in Medicinal Chemistry. Bentham Science Publishers: Hilversum. ISSN 1389-5575; e-ISSN 1875-5607
|  |
| Trefwoorden |
Ion channels > Calcium channels
Ion channels > Potassium channels
Conus monile Hwass, 1792 [WoRMS]
Marien/Kust |
| Author keywords |
Indian cone snails; Conus monile; Fingerprint of conotoxins; Pharmacological targets; Voltage gated sodium channels; ; |
| Auteurs | | Top |
- Ramasamy, M. S.
- Manikandan, S.
|
|
|
| Abstract |
The oceans are a source of combinatorial library of unique natural products, ‘not found in the terrestrial environment’. Marine invertebrates such as sponges, molluscs, bryozoans, tunicates (Urochordata) and their associated microorganisms are the major representatives of promising bioactive compounds. Among these, the predatory molluscan cone snails have evolved with highly structured small and complex array of peptides (more than 50,000) linked to their prey capture and defence. These peptides have become a valuable source of neuro pharmacological targets as many of them selectively modulate ion channels and transporters. A group of scientists from United States, Europe, Australia, Israel and China has characterized drugs for neuropathic pain and pharmacological targets from the peptides of a few cone snail species. Several are now in clinical and preclinical development. Less than 1% of the cono peptides are pharmacologically characterized. India has a diversity of 20-30% of total cone snail species distributed worldwide. A group of Indian Scientists has made promising drug discovery programs from Conus peptides. This review will focus on the Conus peptides from Indian cone snails species, their neuro pharmacological targets and future directions. |
IMIS is ontwikkeld en wordt gehost door het VLIZ.
