Zoeken
Zoeken kan via de modus 'eenvoudig zoeken' (één veld) of uitgebreid via 'geavanceerd zoeken' (meerdere velden). Zo kan je bv. zoeken op een combinatie van een auteursnaam (auteur), een jaartal (jaar) en een documenttype.
Boekenmand
Nuttige resultaten kan je aanvinken en toevoegen aan een mandje. De inhoud hiervan kan je exporteren of afdrukken (naar bv. PDF).
RSS
Op de hoogte blijven van nieuw toegevoegde publicaties binnen uw interessegebied? Dit kan door een RSS-feed (?) te maken van jouw zoekopdracht.
nieuwe zoekopdracht
New insights into the causes of human illness due to consumption of azaspiracid contaminated shellfish
Chevallier, O.P.; Graham, S.F.; Alonso, E.; Duffy, C.; Silke, J.; Campbell, K.; Botana, L.M.; Elliott, C.T. (2015). New insights into the causes of human illness due to consumption of azaspiracid contaminated shellfish. NPG Scientific Reports 5(9818): 8 pp. http://dx.doi.org/10.1038/srep09818
In: Scientific Reports (Nature Publishing Group). Nature Publishing Group: London. ISSN 2045-2322; e-ISSN 2045-2322
|   |
| Trefwoorden |
Contamination
Diseases
Fauna > Aquatic organisms > Aquatic animals > Shellfish
Poisoning
Marien/Kust |
| Auteurs | | Top |
- Chevallier, O.P.
- Graham, S.F.
- Alonso, E.
- Duffy, C.
|
- Silke, J.
- Campbell, K.
- Botana, L.M.
- Elliott, C.T.
|
|
| Abstract |
Azaspiracid (AZA) poisoning was unknown until 1995 when shellfish harvested in Ireland caused illness manifesting by vomiting and diarrhoea. Further in vivo/vitro studies showed neurotoxicity linked with AZA exposure. However, the biological target of the toxin which will help explain such potent neurological activity is still unknown. A region of Irish coastline was selected and shellfish were sampled and tested for AZA using mass spectrometry. An outbreak was identified in 2010 and samples collected before and after the contamination episode were compared for their metabolite profile using high resolution mass spectrometry. Twenty eight ions were identified at higher concentration in the contaminated samples. Stringent bioinformatic analysis revealed putative identifications for seven compounds including, glutarylcarnitine, a glutaric acid metabolite. Glutaric acid, the parent compound linked with human neurological manifestations was subjected to toxicological investigations but was found to have no specific effect on the sodium channel (as was the case with AZA). However in combination, glutaric acid (1mM) and azaspiracid (50nM) inhibited the activity of the sodium channel by over 50%. Glutaric acid was subsequently detected in all shellfish employed in the study. For the first time a viable mechanism for how AZA manifests itself as a toxin is presented. |
IMIS is ontwikkeld en wordt gehost door het VLIZ.
