Zoeken
Zoeken kan via de modus 'eenvoudig zoeken' (één veld) of uitgebreid via 'geavanceerd zoeken' (meerdere velden). Zo kan je bv. zoeken op een combinatie van een auteursnaam (auteur), een jaartal (jaar) en een documenttype.
Boekenmand
Nuttige resultaten kan je aanvinken en toevoegen aan een mandje. De inhoud hiervan kan je exporteren of afdrukken (naar bv. PDF).
RSS
Op de hoogte blijven van nieuw toegevoegde publicaties binnen uw interessegebied? Dit kan door een RSS-feed (?) te maken van jouw zoekopdracht.
nieuwe zoekopdracht
Residue levels of enrofloxacin and ciprofloxacin in processed animal by-products used in Atlantic salmon feeds and their long-term carry-over to the edible part of the fish
Berntssen, G; Valdersnes, S; Lunestad, T; Hatlen, B; Alm, M.; Waagbo, R; Buttle, L (2014). Residue levels of enrofloxacin and ciprofloxacin in processed animal by-products used in Atlantic salmon feeds and their long-term carry-over to the edible part of the fish. Aquacult. Nutr. 20(6): 712-721. dx.doi.org/10.1111/anu.12121
In: Aquaculture Nutrition. Blackwell Science: Oxford. ISSN 1353-5773; e-ISSN 1365-2095
|  |
| Trefwoorden |
Salmo salar Linnaeus, 1758 [WoRMS]
Marien/Kust |
| Author keywords |
animal by-products; antibacterials; carry-over model; farmed fish;toxicokinetics |
| Auteurs | | Top |
- Berntssen, G
- Valdersnes, S
- Lunestad, T
- Hatlen, B
|
- Alm, M.
- Waagbo, R
- Buttle, L
|
|
| Abstract |
Residue levels of the antibacterials enrofloxacin and ciprofloxacin were analysed in 15 commercially relevant animal by-products (ABPs). Enrofloxacin was detected in all ABPs, and ciprofloxacin was detected in 11 of 15 ABP samples. Feed to muscle and skin carry –over of low background enro- and ciprofloxacin levels were assessed by applying a simple toxicokinetic model. The muscle and skin uptake and elimination rates were established in Atlantic salmon (Salmo salar L.) fed enrofloxacin enriched diets (100 µg kg-1 ‘low’ and 4000 µg kg-1 ‘high’) in triplicate for 41 days followed by a 90 days depuration period. The terminal half-lives were 17 ± 0.4 and 18 ± 0.7 days, and uptake rates were 9.3 ± 3.3 and 11 ± 3.1 (day-1) for the ‘low’ and ‘high’ groups, respectively. Only fish fed high background levels had quantifiable levels of the metabolite ciprofloxacin with a formation of 0.25 ± 0.01% day-1. The toxicokinetic carry-over model predicted muscle and skin steady state levels of 1.8 µg kg-1 when fed theoretically high enrofloxacin levels (158 µg kg-1), which is below the EU limit of 100 µg kg-1 for enrofloxacin in finfish food products. The antibacterial residue levels could however be detected in EU food surveillance programmes. |
IMIS is ontwikkeld en wordt gehost door het VLIZ.
