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Development and validation of a method for mercury determination in seawater for the process control of a candidate certified reference material
Sánchez, R.; Snell, J.; Held, A.; Emons, H. (2015). Development and validation of a method for mercury determination in seawater for the process control of a candidate certified reference material. Anal. Bioanal. Chem. 407(21): 6569-6574. dx.doi.org/10.1007/s00216-015-8833-9
In: Analytical and Bioanalytical Chemistry. Springer: Heidelberg. ISSN 1618-2642; e-ISSN 1618-2650
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| Trefwoord |
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| Author keywords |
Mercury; Water Framework Directive (WFD); Seawater; Inductively coupledplasma mass spectrometry (ICP-MS); Method validation; Uncertaintyestimation |
| Auteurs | | Top |
- Sánchez, R.
- Snell, J.
- Held, A.
- Emons, H.
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| Abstract |
A simple, robust and reliable method for mercury determination in seawater matrices based on the combination of cold vapour generation and inductively coupled plasma mass spectrometry (CV-ICP-MS) and its complete in-house validation are described. The method validation covers parameters such as linearity, limit of detection (LOD), limit of quantification (LOQ), trueness, repeatability, intermediate precision and robustness. A calibration curve covering the whole working range was achieved with coefficients of determination typically higher than 0.9992. The repeatability of the method (RSDrep) was 0.5 %, and the intermediate precision was 2.3 % at the target mass fraction of 20 ng/kg. Moreover, the method was robust with respect to the salinity of the seawater. The limit of quantification was 2.7 ng/kg, which corresponds to 13.5 % of the target mass fraction in the future certified reference material (20 ng/kg). An uncertainty budget for the measurement of mercury in seawater has been established. The relative expanded (k = 2) combined uncertainty is 6 %. The performance of the validated method was demonstrated by generating results for process control and a homogeneity study for the production of a candidate certified reference material. |
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