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Thyroid hormone deiodinases during embryonic development of the saltwater crocodile (Crocodylus porosus)
Shepherdley, C.A.; Richardson, S.J.; Evans, B.K.; Kühn, E.R.; Darras, V.M. (2002). Thyroid hormone deiodinases during embryonic development of the saltwater crocodile (Crocodylus porosus). Gen. Comp. Endocrinol. 126(2): 153-164. https://dx.doi.org/10.1006/gcen.2002.7786
In: General and Comparative Endocrinology. Elsevier: New York,. ISSN 0016-6480; e-ISSN 1095-6840
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| Trefwoorden |
Crocodylus porosus Schneider, 1801 [WoRMS]
Marien/Kust |
| Author keywords |
inner ring deiodination; outer ring deiodination; thyroid hormones;development; tissue distribution; saltwater crocodile |
| Auteurs | | Top |
- Shepherdley, C.A.
- Richardson, S.J.
- Evans, B.K.
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| Abstract |
All tissues of the embryonic saltwater crocodile (Crocodylus porosus) gradually increased in weight during development except for lung tissue, which had a peak weight of 1.09 g at day 67, thereafter decreasing in weight. The brain was a relatively large organ. Deiodinase activities in liver, kidney, lung, heart, gut, and brain from day 29 to day 77 of development of the saltwater crocodile were investigated. High-Km reverse triiodothyronine (rT3) outer ring deiodination (ORD) activity was present in all tissues except the brain. Activity ranged from 559 ± 51.3 pmol rT3 deiodinated/mg protein/min in the liver at day 77 to below 10 pmol rT3 deiodinated/mg protein/min in gut, lung, and heart tissue. rT3 ORD increased during development in the liver and kidney but decreased in the gut and lung. Activity in the heart was very low (less than 2 pmol rT3 deiodinated/mg protein/min) and did not change during development. Low-Km thyroxine (T4) ORD in liver and kidney tissue had peaks of activity around day 49 of incubation (0.52 and 0.09 fmol T4 deiodinated/mg protein/min, respectively). After day 49, T4 ORD activity in these tissues decreased. T4 ORD activity in gut, lung, and heart was very low (less than 0.04 fmol T4 deiodinated/mg protein/min), with activity in lung increasing slightly during the rest of development. T4 ORD activity in the brain increased toward day 77 (0.14 ± 0.03 fmol T4 deiodinated/mg protein/min), illustrating its importance in local triiodothyronine (T3) production during brain development. T3 inner ring deiodination activity was present only in the embryonic liver and peaked at day 49 (10.1 fmol T3 deiodinated/mg protein/min), after which activity decreased. |
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