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New natural products identified by combined genomics-metabolomics profiling of marine Streptomyces sp. MP131-18
Paulus, C.; Rebets, Y.; Tokovenko, B.; Nadmid, S.; Terekhova, L.P.; Myronovskyi, M.; Zotchev, S.B.; Rückert, C.; Braig, S.; Zahler, S.; Kalinowski, J.; Luzhetskyy, A. (2017). New natural products identified by combined genomics-metabolomics profiling of marine Streptomyces sp. MP131-18. NPG Scientific Reports 7(42382): 11 pp. http://dx.doi.org/10.1038/srep42382
In: Scientific Reports (Nature Publishing Group). Nature Publishing Group: London. ISSN 2045-2322; e-ISSN 2045-2322
|   |
| Auteurs | | Top |
- Paulus, C.
- Rebets, Y.
- Tokovenko, B.
- Nadmid, S.
|
- Terekhova, L.P.
- Myronovskyi, M.
- Zotchev, S.B.
- Rückert, C.
|
- Braig, S.
- Zahler, S.
- Kalinowski, J.
- Luzhetskyy, A.
|
| Abstract |
Marine actinobacteria are drawing more and more attention as a promising source of new natural products. Here we report isolation, genome sequencing and metabolic profiling of new strain Streptomyces sp. MP131-18 isolated from marine sediment sample collected in the Trondheim Fjord, Norway. The 16S rRNA and multilocus phylogenetic analysis showed that MP131-18 belongs to the genus Streptomyces. The genome of MP131-18 isolate was sequenced, and 36 gene clusters involved in the biosynthesis of 18 different types of secondary metabolites were predicted using antiSMASH analysis. The combined genomics-metabolics profiling of the strain led to the identification of several new biologically active compounds. As a result, the family of bisindole pyrroles spiroindimicins was extended with two new members, spiroindimicins E and F. Furthermore, prediction of the biosynthetic pathway for unusual alpha-pyrone lagunapyrone isolated from MP131-18 resulted in foresight and identification of two new compounds of this family - lagunapyrones D and E. The diversity of identified and predicted compounds from Streptomyces sp. MP131-18 demonstrates that marine-derived actinomycetes are not only a promising source of new natural products, but also represent a valuable pool of genes for combinatorial biosynthesis of secondary metabolites. |
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