Publicaties | Kaarten

nieuwe zoekopdracht

[ meld een fout in dit record ]mandje (0): toevoegen | toon Print deze pagina
Immune-suppression by OsHV-1 viral infection causes fatal bacteraemia in Pacific oysters
de Lorgeril, J.; Lucasson, A.; Petton, B.; Toulza, E.; Montagnani, C.; Clerissi, C.; Vidal-Dupiol, J.; Chaparro, C.; Galinier, R.; Escoubas, J.-M.; Haffner, Ph.; Dégremont, L.; Charrière, G.M.; Lafont, M.; Delort, A.; Vergnes, A.; Chiarello, M.; Faury, N.; Rubio, T.; Leroy, M.A.; Pérignon, A.; Régler, D.; Morga, B.; Alunno-Bruscia, M.; Boudry, P.; Le Roux, F.; Destoumieux-Garzon, D.; Gueguen, Y.; Mitta, G. (2018). Immune-suppression by OsHV-1 viral infection causes fatal bacteraemia in Pacific oysters. Nature Comm. 9(1): 14 pp. https://dx.doi.org/10.1038/s41467-018-06659-3
In: Nature Communications. Nature Publishing Group: London. ISSN 2041-1723; e-ISSN 2041-1723
Peer reviewed article  
Beschikbaar in  Auteurs 
Auteurs  Top 
  • de Lorgeril, J.
  • Lucasson, A.
  • Petton, B.
  • Toulza, E.
  • Montagnani, C.
  • Clerissi, C.
  • Vidal-Dupiol, J.
  • Chaparro, C.
  • Galinier, R.
  • Escoubas, J.-M.
  • Haffner, Ph.
  • Dégremont, L.
  • Charrière, G.M.
  • Lafont, M.
  • Delort, A.
  • Vergnes, A.
  • Chiarello, M.
  • Faury, N.
  • Rubio, T.
  • Leroy, M.A.
  • Pérignon, A.
  • Régler, D.
  • Morga, B.
  • Alunno-Bruscia, M.
  • Boudry, P.
  • Le Roux, F.
  • Destoumieux-Garzon, D.
  • Gueguen, Y.
  • Mitta, G.
Abstract
    Infectious diseases are mostly explored using reductionist approaches despite repeated evidence showing them to be strongly influenced by numerous interacting host and environmental factors. Many diseases with a complex aetiology therefore remain misunderstood. By developing a holistic approach to tackle the complexity of interactions, we decipher the complex intra-host interactions underlying Pacific oyster mortality syndrome affecting juveniles of Crassostrea gigas, the main oyster species exploited worldwide. Using experimental infections reproducing the natural route of infection and combining thorough molecular analyses of oyster families with contrasted susceptibilities, we demonstrate that the disease is caused by multiple infection with an initial and necessary step of infection of oyster haemocytes by the Ostreid herpesvirus OsHV-1 µVar. Viral replication leads to the host entering an immune-compromised state, evolving towards subsequent bacteraemia by opportunistic bacteria. We propose the application of our integrative approach to decipher other multifactorial diseases that affect non-model species worldwide
Alle informatie in het Integrated Marine Information System (IMIS) valt onder het VLIZ Privacy beleid Top | Auteurs 
IMIS is ontwikkeld en wordt gehost door het VLIZ.