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Complex mammalian-like haematopoietic system found in a colonial chordate
Rosental, B.; Kowarsky, M.; Seita, J.; Corey, D.M.; Ishizuka, K.J.; Palmeri, K.J.; Chen, S.-Y.; Sinha, R.; Okamoto, J.; Mantalas, G.; Manni, L.; Raveh, T.; Clarke, D.N.; Tsai, J.M.; Newman, A.M.; Neff, N.F.; Nolan, G.P.; Quake, S.R.; Weissman, I.L.; Voskoboynik, A. (2018). Complex mammalian-like haematopoietic system found in a colonial chordate. Nature (Lond.) 564(7736): 425-429. https://dx.doi.org/10.1038/s41586-018-0783-x
In: Nature: International Weekly Journal of Science. Nature Publishing Group: London. ISSN 0028-0836; e-ISSN 1476-4687, meer
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| Trefwoord |
Botryllus schlosseri (Pallas, 1766) [WoRMS]
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| Auteurs | | Top |
- Rosental, B.
- Kowarsky, M.
- Seita, J.
- Corey, D.M.
- Ishizuka, K.J.
- Palmeri, K.J.
- Chen, S.-Y.
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- Sinha, R.
- Okamoto, J.
- Mantalas, G.
- Manni, L.
- Raveh, T.
- Clarke, D.N.
- Tsai, J.M.
|
- Newman, A.M.
- Neff, N.F.
- Nolan, G.P.
- Quake, S.R.
- Weissman, I.L.
- Voskoboynik, A.
|
| Abstract |
Haematopoiesis is an essential process that evolved in multicellular animals. At the heart of this process are haematopoietic stem cells (HSCs), which are multipotent and self-renewing, and generate the entire repertoire of blood and immune cells throughout an animal’s life. Although there have been comprehensive studies on self-renewal, differentiation, physiological regulation and niche occupation in vertebrate HSCs, relatively little is known about the evolutionary origin and niches of these cells. Here we describe the haematopoietic system of Botryllus schlosseri, a colonial tunicate that has a vasculature and circulating blood cells, and interesting stem-cell biology and immunity characteristics. Self-recognition between genetically compatible B. schlosseri colonies leads to the formation of natural parabionts with shared circulation, whereas incompatible colonies reject each other. Using flow cytometry, whole-transcriptome sequencing of defined cell populations and diverse functional assays, we identify HSCs, progenitors, immune effector cells and an HSC niche, and demonstrate that self-recognition inhibits allospecific cytotoxic reactions. Our results show that HSC and myeloid lineage immune cells emerged in a common ancestor of tunicates and vertebrates, and also suggest that haematopoietic bone marrow and the B. schlosseri endostyle niche evolved from a common origin. |
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