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Automated chemical sensing unit integration for parallel optical interrogation
Hernandez, A.L.; Dortu, F.; Veenstra, T.; Ciaurriz, P.; Casquel, R.; Cornago, I.; Horsten, H.V.; Tellechea, E.; Maigler, M.V.; Fernández, F.; Holgado, M. (2019). Automated chemical sensing unit integration for parallel optical interrogation. Sensors 19(4): 878. https://dx.doi.org/10.3390/s19040878
In: Sensors. MDPI: Basel. e-ISSN 1424-8220
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| Trefwoord |
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| Author keywords |
optical sensor; sensing; resonant nanopillars; parallel detection;microfluidics; automatic system |
| Auteurs | | Top |
- Hernandez, A.L.
- Dortu, F.
- Veenstra, T.
- Ciaurriz, P.
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- Casquel, R.
- Cornago, I.
- von Horsten, H.
- Tellechea, E.
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- Maigler, M.V.
- Fernández, F.
- Holgado, M.
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| Abstract |
We report the integration of an automated chemical optical sensing unit for the parallel interrogation of 12 BICELLs in a sensing chip. The work was accomplished under the European Project Enviguard (FP7-OCEAN-2013-614057) with the aim of demonstrating an optical nano-biosensing unit for the in-situ detection of various chemical pollutants simultaneously in oceanic waters. In this context, we designed an optical sensing chip based on resonant nanopillars (R-NPs) transducers organized in a layout of twelve biophotonic sensing cells (BICELLs). The sensing chip is interrogated in reflection with a 12-channels optical spectrometer equipped with an embedded computer-on-chip performing image processing for the simultaneous acquisition and analysis (resonant mode fitting) of the 12 spectra. A microfluidic chip and an automated flow control system composed of four pumps and a multi-path micro-valve makes it possible to drive different complex protocols. A rack was designed ad-hoc for the integration of all the modules. As a proof of concept, fluids of different refractive index (RI) were flowed in the system in order to measure the time response (sensogram) of the R-NPs under optical reflectance, and assess the sensors’ bulk sensitivity (285.9 ± 16.4 nm/RIU) and Limit of Detection (LoD) (2.95 × 10−6 RIUS). The real-time response under continuous flow of a sensor chip based on R-NP is showed for the first time, obtaining 12 sensograms simultaneously, featuring the unit as a potential excellent multiplexed detection system. These results indicate the high potential of the developed chemical sensing unit to be used for in-situ, multiplex and automatic optical biosensing. |
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