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Genomics–metabolomics profiling disclosed marine Vibrio spartinae 3.6 as a producer of a new branched side chain prodigiosin
Vitale, G.A.; Sciarretta, M.; Palma Esposito, F.; January, G.G.; Giaccio, M.; Bunk, B.; Spröer, C.; Bajerski, F.; Power, D.; Festa, C.; Monti, M.C.; D’Auria, M.V.; de Pascale, D. (2020). Genomics–metabolomics profiling disclosed marine Vibrio spartinae 3.6 as a producer of a new branched side chain prodigiosin. J. Nat. Prod. 83(5): 1495-1504. https://dx.doi.org/10.1021/acs.jnatprod.9b01159
In: Journal of Natural Products. American Chemical Society/American Society of Pharmacognosy: Washington DC. ISSN 0163-3864; e-ISSN 1520-6025
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| Trefwoorden |
ASSEMBLEPlus Transnational Access
Scientific Publication
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| Auteurs | | Top |
- Vitale, G.A.
- Sciarretta, M.
- Palma Esposito, F.
- January, G.G.
- Giaccio, M.
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- Bunk, B.
- Spröer, C.
- Bajerski, F.
- Power, D.
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- Festa, C.
- Monti, M.C.
- D’Auria, M.V.
- de Pascale, D.
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| Abstract |
A wide range of prescreening tests for antimicrobial activity of 59 bacterial isolates from sediments of Ria Formosa Lagoon (Algarve, Portugal) disclosed Vibrio spartinae 3.6 as themost active antibacterial producing strain. This bacterial strain,which has not previously been submitted for chemical profiling,was subjected to de novo whole genome sequencing, which aided inthe discovery and elucidation of a prodigiosin biosynthetic genecluster that was predicted by the bioinformatic tool KEGG BlastKoala. Comparative genomics led to the identification of anew membrane di-iron oxygenase-like enzyme, annotated asVspart_02107, which is likely to be involved in the biosynthesisof cycloprodigiosin and analogues. The combined genomics−metabolomics profiling of the strain led to the isolation andidentification of one new branched-chain prodigiosin (5) and to the detection of two new cyclic forms. Furthermore, the evaluationof the minimum inhibitory concentrations disclosed the major prodigiosin as very effective against multi-drug-resistant pathogens including Stenotrophomonas maltophilia, a clinical isolate of Listeria monocytogenes, as well as some human pathogens reported by the World Health Organization as prioritized targets. |
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