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Additional screening of bioactivities in the Turkish gorgonian Paramuricea clavata (Risso, 1826) with isolation of secondary metabolites
Korpayev, S.; Heydari, H.; Koc, A.; Gözcelioglu, B.; Konuklugil, B. (2020). Additional screening of bioactivities in the Turkish gorgonian Paramuricea clavata (Risso, 1826) with isolation of secondary metabolites. Cah. Biol. Mar. 61: 25-32. https://dx.doi.org/10.21411/CBM.A.EB81DEF7
In: Cahiers de Biologie Marine. Station Biologique de Roscoff: Paris. ISSN 0007-9723; e-ISSN 2262-3094
|  |
| Trefwoorden |
Paramuricea clavata (Risso, 1827) [WoRMS]
Marien/Kust |
| Author keywords |
acetylcholinesterase inhibitory; antioxidant; antimicrobial; cytotoxicity; paramuricea clavata |
| Auteurs | | Top |
- Korpayev, S.
- Heydari, H.
- Koc, A.
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- Gözcelioglu, B.
- Konuklugil, B.
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| Abstract |
During the course of our investigation for isolation of biological active compounds from marine organisms in the Turkish seas, we looked for secondary metabolites and bioactivities in the soft coral, Paramuricea clavata (Risso, 1826) collected from the coast of Ayvalık (Turkish coasts). As a result of this study, β-sitosterol and diheptyl phthalate have been isolated from P.clavata following their structural identification by NMR spectrometry and their subsequent comparison to the existent spectra dataset. The antioxidant potential of crude extracts of P. clavata was determined by the scavenging of superoxide, nitric oxide radicals and DPPH assays. In addition, the cytotoxic activity of crude extracts was tested against HCT-116 colon cancer cell lines by MTT assay. The P. clavata extract decreased HCT-116 and HEP-2 cancer cells viability significantly between 10-200 µg.mL-1 dose range after 72 h incubation. The screening for free radical scavenging bioactivities by DPPH, SO and NO displayed IC50: 231.23 ± 0.4, 228.9 ± 0.32 and 243.8 ± 0.46 µg.mL-1 respectively for the dried extract, confirming its noteworthy source of antioxidant compounds. While the extract exhibits the highest tyrosinase inhibitory activity (IC50: 73.73 ± 2.31 µg.mL-1), moderate antimicrobial activities against gram positive, gram negative and yeast strains, it did not seem to display acetylcholinesterase inhibitory activity. |
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