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Lindane-induced macrophage activating factor (MAF) production by peripheral blood leukocytes (PBLs) of rainbow trout (Oncorhynchus mykiss): involvement of intracellular cAMP mobilization Duchiron, C.; Reynaud, S.; Deschaux, P. (2002). Lindane-induced macrophage activating factor (MAF) production by peripheral blood leukocytes (PBLs) of rainbow trout (Oncorhynchus mykiss): involvement of intracellular cAMP mobilization. Aquat. Toxicol. 56(2): 81-91. https://dx.doi.org/10.1016/S0166-445X(01)00193-X In: Aquatic Toxicology. Elsevier Science: Tokyo; New York; London; Amsterdam. ISSN 0166-445X; e-ISSN 1879-1514

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Beschikbaar in	Auteurs
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Trefwoorden

Aquatic organisms > Marine organisms > Fish > Marine fish Chemical compounds > Organic compounds > Hydrocarbons > Halogenated hydrocarbons > Chlorinated hydrocarbons > Lindane Fishes > Osteichthyes > Salmoniformes > Salmonidae > Salmo > Freshwater fishes > Rainbow trout Toxicology Oncorhynchus mykiss (Walbaum, 1792) [WoRMS] Marien/Kust

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Auteurs		Top
Duchiron, C., correspondent Reynaud, S. Deschaux, P.

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Abstract

We studied the in vitro effects of the insecticide lindane (2.5-50 μM) on macrophage activating factor (MAF) production by the peripheral blood leukocytes (PBLs) in rainbow trout. The MAF production induced by the mitogens concanavalin A (ConA) and phorbol-12-myristate-13-acetate (PMA) was not modified by lindane pre-treatment. But lindane alone (2.5-25 μM) stimulated the secretion of MAF by PBLs. Intracellular calcium levels ([Ca2+]i) was measured over 6 min by spectrofluorimetry using Indo-1/AM as fluorescent probe. Lindane (25-100 μM) significantly increased the [Ca2+]i in PBLs, but had no effect on calcium at the dose that caused MAF secretion. Moreover, the effect of lindane on MAF production was potentiated by the inhibitor of phosphodiesterase, isobutylmethylxanthin (IBMX). Lindane also directly increased adenosine monophosphate cyclic (cAMP) in PBLs over the same concentration range that it stimulated MAF production by PBLs. Taken together, these results suggest that lindane increase MAF production by acting on intracellular cAMP concentrations. Moreover, the capacity of this insecticide to act on the [Ca+]i or on the intracellular concentrations of cAMP according to the dose used could possibly explain its contradictory effects earlier observed on immunity.

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