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Marine pharmacognosy: an overview of marine-derived pharmaceuticals
Bisaria, K.; Sinha, S.; Srivastava, A.; Singh, R. (2020). Marine pharmacognosy: an overview of marine-derived pharmaceuticals, in: Nathani, N.M. et al. Marine niche: applications in pharmaceutical sciences. pp. 361-381. https://dx.doi.org/10.1007/978-981-15-5017-1_20
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| Trefwoorden |
Porifera [WoRMS]
Marien/Kust |
| Author keywords |
Marine drugs; Anti-microbial agents; Sponge; Bioactive molecules from marine |
| Auteurs | | Top |
- Bisaria, K.
- Sinha, S.
- Srivastava, A.
- Singh, R.
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| Abstract |
Medical science has come a long way in improving the life span and its quality. However, we still face challenges regarding a range of incurable diseases, developing resistance to current prognosis, as well as in the lack of new sources for drug development. Consequently, pharmaceutical industries are constantly in the search for new and advanced resources to produce safe and functional drugs to combat these challenges. Marine biosphere is one of the largest and intricate biospheres as water covers more than 70% of the earth inhabiting a number of flora and fauna. In the hostile marine environment, as part of their adaptation mechanisms, organisms produce specific secondary metabolites to survive in the ocean. These metabolites have very high biological activity and are explored for their potential therapeutic application. To date, seven marine-derived drugs have been approved as “first-in-class drugs” and several are in the clinical and pre-clinical pipeline. These drugs are successfully used in the market for the treatment of cancer, viral diseases, chronic pain, and to lower blood triglyceride levels. This chapter presents an overview of biodiversity in marine life, drug development, marine bioactive agents, and challenges faced in drug discovery, elucidating that the ocean is a largely untapped source of new-era pharmaceuticals. |
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