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Effect of extraction procedures on the chemical structure, antitumor and anticoagulant properties of ulvan from Ulva lactuca of Tunisia coast
Guidara, M.; Yaich, H.; Amor, I.B.; Fakhfakh, J.; Gargouri, J.; Lassoued, S.; Blecker, C.; Richel, A.; Attia, H.; Garna, H. (2021). Effect of extraction procedures on the chemical structure, antitumor and anticoagulant properties of ulvan from Ulva lactuca of Tunisia coast. Carbohydrate Polymers 253: 117283. https://hdl.handle.net/10.1016/j.carbpol.2020.117283
In: Carbohydrate Polymers. Elsevier SCI Ltd: Oxford. ISSN 0144-8617; e-ISSN 1879-1344
Peer reviewed article  
Beschikbaar in  Auteurs 
Trefwoorden
    Ulva lactuca Linnaeus, 1753 [WoRMS]
    Marien/Kust
Author keywords
    Ulvans; Extraction procedures; FTIR; NMR; Cytotoxic activity; Anticoagulant activity
Auteurs  Top 
  • Guidara, M.
  • Yaich, H.
  • Amor, I.B.
  • Fakhfakh, J.
  • Gargouri, J.
  • Lassoued, S.
  • Blecker, C.
  • Richel, A.
  • Attia, H.
  • Garna, H.
Abstract
    The effect of extraction procedures on chemical composition, structural, antitumor and anticoagulant properties of the sulphated polysaccharide ‘ulvan’ from the green seaweed Ulva lactuca were investigated. The structural features of ulvans were carried out by FTIR and by one- and two- dimensional 1H and 13C NMR spectroscopic. The ulvans were mainly composed of rhamnose, xylose, and uronic acid. Chemical and spectroscopic analyses demonstrated that ulvans were constituted of (1→4)-β-glucuronic acid, (1→3,4)-α-L-rhamnose-3-sulphate and (1→4)-α-xylose.

    The extraction procedures effect were observed in chemical structure, Mw and biological activities. Cytotoxic activity of enzymatic-chemical extract on cervical cancer cells (HeLa) (IC50 = 1000 μg/mL) was higher than on normal peripheral blood lymphocytes cells (PBL). Acid extracts promoted to reduce HeLa cells and to grow PBL cells. At high concentrations, acid extracts showed the highest APTT and TT clotting time. Antitumoral and anticoagulant activities of ulvans from Ulva lactuca promote their use as effective therapeutic agent.

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