Zoeken
Zoeken kan via de modus 'eenvoudig zoeken' (één veld) of uitgebreid via 'geavanceerd zoeken' (meerdere velden). Zo kan je bv. zoeken op een combinatie van een auteursnaam (auteur), een jaartal (jaar) en een documenttype.
Boekenmand
Nuttige resultaten kan je aanvinken en toevoegen aan een mandje. De inhoud hiervan kan je exporteren of afdrukken (naar bv. PDF).
RSS
Op de hoogte blijven van nieuw toegevoegde publicaties binnen uw interessegebied? Dit kan door een RSS-feed (?) te maken van jouw zoekopdracht.
nieuwe zoekopdracht
Mechanism of the potential therapeutic candidate Bacillus subtilis BSXE-1601 against shrimp pathogenic vibrios and multifunctional metabolites biosynthetic capability of the strain as predicted by genome analysis
Wang, D.; Li, J.; Zhu, G.; Zhao, K.; Jiang, W.; Li, H.; Wang, W.; Kumar, V.; Dong, S.; Zhu, W.; Tian, X. (2020). Mechanism of the potential therapeutic candidate Bacillus subtilis BSXE-1601 against shrimp pathogenic vibrios and multifunctional metabolites biosynthetic capability of the strain as predicted by genome analysis. Front. Microbiol. 11: 581802. https://hdl.handle.net/10.3389/fmicb.2020.581802
In: Frontiers in Microbiology. Frontiers Media: Lausanne. ISSN 1664-302X; e-ISSN 1664-302X
|   |
| Trefwoorden |
Bacillus subtilis Cohen, 1872 [WoRMS]
Marien/Kust |
| Auteurs | | Top |
- Wang, D.
- Li, J.
- Zhu, G.
- Zhao, K.
|
- Jiang, W.
- Li, H.
- Wang, W.
- Kumar, V.
|
- Dong, S.
- Zhu, W.
- Tian, X.
|
| Abstract |
The global shrimp industry has suffered bacterial diseases caused mainly by Vibrio species. The typical vibriosis, acute hepatopancreatic necrosis disease (AHPND), has resulted in mass mortality and devastating economic losses. Thus, therapeutic strategies are highly needed to decrease the risk of vibriosis outbreaks. Herein, we initially identified that the growth of the causative agent of AHPND, Vibrio parahaemolyticus (VPAHPND) and other vibrios in Pacific white shrimp (Litopenaeus vannamei) was inhibited by a Bacillus subtilis strain BSXE-1601. The natural products amicoumacins A, B, and C were purified from the cell-free supernatant from the strain BSXE-1601, but only amicoumacin A was demonstrated to be responsible for this anti-Vibrio activity. Our discovery provided the first evidence that amicoumacin A was highly active against shrimp pathogens, including the representative strain VPAHPND. Furthermore, we elucidated the amicoumacin A biosynthetic gene cluster by whole genome sequencing of the B. subtilis strain BSXE-1601. In addition to amicoumacin A, the strain BSXE-1601 genome harbored other genes encoding bacillibactin, fengycin, surfactin, bacilysin, and subtilosin A, all of which have previously reported antagonistic activities against pathogenic strains. The whole-genome analysis provided unequivocal evidence in support of the huge potential of the strain BSXE-1601 to produce diverse biologically antagonistic natural products, which may facilitate further studies on the effective therapeutics for detrimental diseases in shrimp. |
IMIS is ontwikkeld en wordt gehost door het VLIZ.
