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Structural characterization and protective effects of polysaccharide from Gracilaria lemaneiformis on LPS-induced injury in IEC-6 cells
Li, X.; Gong, Y.; Yao, W.; Chen, X.; Xian, J.; You, L.; Fardim, P. (2021). Structural characterization and protective effects of polysaccharide from Gracilaria lemaneiformis on LPS-induced injury in IEC-6 cells. Food Chemistry: X 12: 100157. https://dx.doi.org/10.1016/j.fochx.2021.100157
In: Food Chemistry: X. Elsevier Ltd: Amsterdam. e-ISSN 2590-1575
|   |
| Trefwoorden |
Gracilaria lemaneiformis (Bory de Saint-Vincent) Greville, 1830 [WoRMS]
Marien/Kust |
| Author keywords |
Gracilaria lemaneiformis; Sulfated polysaccharide; Anti-inflammatory activity; Tight junction |
| Auteurs | | Top |
- Li, X.
- Gong, Y.
- Yao, W.
- Chen, X.
|
- Xian, J.
- You, L.
- Fardim, P.
|
|
| Abstract |
This study was aimed to characterize Gracilaria lemaneiformis polysaccharides and evaluate their protective effects on Lipopolysaccharide-induced injury in IEC-6 cells. The G. lemaneiformis polysaccharide was degraded by UV/H2O2 treatment and purified to three fractions named GLP-1.0 M, GLP-1.4 M and GLP-1.6 M. The purified fractions were mainly composed of galactose, glucose and xylose. The structural analysis showed that GLP-1.6 M was a typical sulfated red alga polysaccharide containing the linear backbone of β-(1 → 3)- and α-(1 → 4)-linked galactosyl residues, anhydro-galactose units. In the Lipopolysaccharide-induced IEC-6 cells model, GLP-1.6 M exerted the strongest in vitro anti-inflammatory activity by inhibiting the release and expressions of tumor necrosis factor-α, interleukin-6 and interleukin-1β by 89.93%, 67.82% and 38.06%, respectively. Meanwhile, GLP-1.6 M enhanced the intestinal barrier function via up-regulating the expressions of tight junctions and mucin. Therefore, the purified polysaccharide from G. lemaneiformis could be a promising candidate for maintaining intestinal health in the food and pharmaceutical industries. |
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