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Indole decreases the virulence of the bivalve model pathogens Vibrio tasmaniensis LGP32 and Vibrio crassostreae J2-9
Zhang, S.; Yang, Q.; Fu, S.; Janssen, C.R.; Eggermont, M.; Defoirdt, T. (2022). Indole decreases the virulence of the bivalve model pathogens Vibrio tasmaniensis LGP32 and Vibrio crassostreae J2-9. NPG Scientific Reports 12(1): 5749. https://dx.doi.org/10.1038/s41598-022-09799-1
In: Scientific Reports (Nature Publishing Group). Nature Publishing Group: London. ISSN 2045-2322; e-ISSN 2045-2322
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| Trefwoorden |
Vibrio crassostreae Faury, Saulnier, Thompson, Gay, Swings & Roux, 2004 [WoRMS]; Vibrio tasmaniensis Thompson, Thompson & Swings, 2003 [WoRMS]
Marien/Kust |
| Auteurs | | Top |
- Zhang, S.
- Yang, Q.
- Fu, S.
|
- Janssen, C.R.
- Eggermont, M.
- Defoirdt, T.
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|
| Abstract |
Indole signaling plays an important role in bacterial pathogenesis. In this study, the impact of indole on biofilm formation, swimming and swarming motility were explored in Vibrio tasmaniensis LGP32 and Vibrio crassostreae J2-9, two model pathogens of bivalves. The results showed that indole decreased swimming and swarming motility in both strains, and decreased biofilm formation in V. crassostreae J2-9. Furthermore, indole affected a large number of genes at RNA level, including genes related to metabolism, ABC transporters, flagellar assembly, chemotaxis, and response regulators. Finally, the bacterial virulence towards mussel larvae was decreased by pretreatment with indole in both V. tasmaniensis LGP32 and V. crassostreae J2-9. After 5 days, the survival rate of mussel larvae increased 2.4-fold and 2.8-fold in mussel larvae challenged with V. tasmaniensis LGP32 pretreated with 200 µM and 500 µM indole, respectively. The survival rate of mussel larvae increased 1.5-fold and 1.9-fold in mussel larvae challenged with V. crassostreae J2-9 pretreated with 200 µM and 500 µM indole, respectively. These data indicate that indole has a significant impact on the virulence of V. tasmaniensis LGP32 and V. crassostreae J2-9, and indole signaling could be a promising target for antivirulence therapy. |
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