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First report of steroid derivatives isolated from starfish Acanthaster planci with anti-bacterial, anti-cancer and anti-diabetic activities
Abd El Hafez, M.S.M.; Abd El Aziz Okbah, M.; Ibrahim, H.A.H.; Abd El Rahim Hussein, A.; Abd El Moneim, N.A.; Ata, A. (2022). First report of steroid derivatives isolated from starfish Acanthaster planci with anti-bacterial, anti-cancer and anti-diabetic activities. Nat. Prod. Res. 36(21): 5545-5552. https://dx.doi.org/10.1080/14786419.2021.2021200
In: Natural Product Research. Taylor & Francis: Abingdon. ISSN 1478-6419; e-ISSN 1478-6427
Peer reviewed article  
Beschikbaar in  Auteurs 
Trefwoorden
    Acanthaster planci (Linnaeus, 1758) [WoRMS]
    Marien/Kust
Author keywords
    Bioactive compounds; steroids; starfish; Acanthaster planci; NMR
Auteurs  Top 
  • Abd El Hafez, M.S.M.
  • Abd El Aziz Okbah, M.
  • Ibrahim, H.A.H.
  • Abd El Rahim Hussein, A.
  • Abd El Moneim, N.A.
  • Ata, A.
Abstract
    Chemical studies on Acanthaster planci have afforded two steroids, 5α-cholesta-24-en-3β,20β-diol-23-one (1) and 5α-cholesta-9(11)-en-3β, 20β-diol (2). Structures compounds 1 and 2 were determined with the help of spectroscopic studies. Compound 1 showed strong antibacterial activity (21.0 ± 0.06 mm) against P. aeruginosa. Compounds 1 and 2 were also active against human breast carcinoma cells (MCF-7) with LC50 values of 49 ± 1.6 and 57.5 ± 1.5 μg/ml, respectively. This bioactivity was comparable to the currently used anticancer agent, cisplatin (LC50 46 ± 1.1 µg/ml). Compounds 1 and 2 exhibited anti-α-glucosidase activity with IC50 values of 58 ± 0.8 and 55 ± 0.5 µg/ml, respectively, whereas IC50 of Acarbose as a positive control was found to be 36 ± 0.4 µg/ml in our bioassay.
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