Publicaties | Kaarten

nieuwe zoekopdracht

[ meld een fout in dit record ]mandje (0): toevoegen | toon Print deze pagina
Evolution of the germline mutation rate across vertebrates
Bergeron, L.A.; Besenbacher, S.; Zheng, J.; Li, P.; Bertelsen, M.F.; Quintard, B.; Hoffman, J.I.; Li, Z.; St Leger, J.; Shao, C.; Stiller, J.; Gilbert, M.T.P.; Schierup, M.H.; Zhang, G. (2023). Evolution of the germline mutation rate across vertebrates. Nature (Lond.) 615(7951): 285–291. https://dx.doi.org/10.1038/s41586-023-05752-y
In: Nature: International Weekly Journal of Science. Nature Publishing Group: London. ISSN 0028-0836; e-ISSN 1476-4687, meer
Is gerelateerd aan:
(2023). Rate at which mutations are passed to offspring established for various animal species. Nature (Lond.) 615(7951): [1-2]. https://dx.doi.org/10.1038/d41586-023-00296-7, meer
Peer reviewed article  
Beschikbaar in  Auteurs 
Trefwoord
    Marien/Kust
Auteurs  Top 
  • Bergeron, L.A.
  • Besenbacher, S.
  • Zheng, J.
  • Li, P.
  • Bertelsen, M.F.
  • Quintard, B.
  • Hoffman, J.I.
  • Li, Z.
  • St Leger, J.
  • Shao, C.
  • Stiller, J.
  • Gilbert, M.T.P.
  • Schierup, M.H.
  • Zhang, G.
Abstract
    The germline mutation rate determines the pace of genome evolution and is an evolving parameter itself. However, little is known about what determines its evolution, as most studies of mutation rates have focused on single species with different methodologies. Here we quantify germline mutation rates across vertebrates by sequencing and comparing the high-coverage genomes of 151 parent–offspring trios from 68 species of mammals, fishes, birds and reptiles. We show that the per-generation mutation rate varies among species by a factor of 40, with mutation rates being higher for males than for females in mammals and birds, but not in reptiles and fishes. The generation time, age at maturity and species-level fecundity are the key life-history traits affecting this variation among species. Furthermore, species with higher long-term effective population sizes tend to have lower mutation rates per generation, providing support for the drift barrier hypothesis. The exceptionally high yearly mutation rates of domesticated animals, which have been continually selected on fecundity traits including shorter generation times, further support the importance of generation time in the evolution of mutation rates. Overall, our comparative analysis of pedigree-based mutation rates provides ecological insights on the mutation rate evolution in vertebrates.
Alle informatie in het Integrated Marine Information System (IMIS) valt onder het VLIZ Privacy beleid Top | Auteurs 
IMIS is ontwikkeld en wordt gehost door het VLIZ.