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Guidance on harmonised methodologies for human health, animal health and ecological risk assessment of combined exposure to multiple chemicals More, Simon John; Bampidis, Vasileios; Benford, Diane; Bennekou, Susanne Hougaard; Bragard, Claude; Halldorsson, Thorhallur Ingi; Hernández‐Jerez, Antonio F; Koutsoumanis, Konstantinos; Naegeli, Hanspeter; Schlatter, Josef R; Silano, Vittorio; Nielsen, Søren Saxmose; Schrenk, Dieter; Turck, Dominique; Younes, Maged; Benfenati, Emilio; Castle, Laurence; Cedergreen, Nina; Hardy, Anthony; Laskowski, Ryszard; Leblanc, Jean Charles; Kortenkamp, Andreas; Ragas, Ad; Posthuma, Leo; Svendsen, Claus; Solecki, Roland; Testai, Emanuela; Dujardin, Bruno; Kass, George EN; Manini, Paola; Jeddi, Maryam Zare; Dorne, Jean‐Lou CM; Hogstrand, Christer (2019). Guidance on harmonised methodologies for human health, animal health and ecological risk assessment of combined exposure to multiple chemicals. EFSA Journal 17(3): e05634. https://dx.doi.org/10.2903/j.efsa.2019.5634 In: EFSA Journal. European Food Safety Authority: Parma. ISSN 2314-9396; e-ISSN 1831-4732

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Beschikbaar in
VLIZ: Open access 395310 [ download pdf ]

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Trefwoord

Marien/Kust

Author keywords

harmonised methodologies, risk assessment, combined exposure to multiple chemicals, mixtures, dose addition, response addition, interactions

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Abstract

This Guidance document describes harmonised risk assessment methodologies for combined exposure to multiple chemicals for all relevant areas within EFSA's remit, i.e. human health, animal health and ecological areas. First, a short review of the key terms, scientific basis for combined exposure risk assessment and approaches to assessing (eco)toxicology is given, including existing frameworks for these risk assessments. This background was evaluated, resulting in a harmonised framework for risk assessment of combined exposure to multiple chemicals. The framework is based on the risk assessment steps (problem formulation, exposure assessment, hazard identification and characterisation, and risk characterisation including uncertainty analysis), with tiered and stepwise approaches for both whole mixture approaches and component-based approaches. Specific considerations are given to component-based approaches including the grouping of chemicals into common assessment groups, the use of dose addition as a default assumption, approaches to integrate evidence of interactions and the refinement of assessment groups. Case studies are annexed in this guidance document to explore the feasibility and spectrum of applications of the proposed methods and approaches for human and animal health and ecological risk assessment. The Scientific Committee considers that this Guidance is fit for purpose for risk assessments of combined exposure to multiple chemicals and should be applied in all relevant areas of EFSA's work. Future work and research are recommended.

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