Publicaties | Kaarten

nieuwe zoekopdracht

[ meld een fout in dit record ]mandje (0): toevoegen | toon Print deze pagina
Somatic evolution of marine transmissible leukemias in the common cockle, Cerastoderma edule
Bruzos, A.L.; Santamarina, M.; Garcia-Souto, D.; Diaz, S.; Rocha, S.; Zamora, J.; Lee, Y.A.; Vina-Feas, A.; Quail, M.A.; Otero, I.; Pequeno-Valtierra, A.; Temes, J.; Rodriguez-Castro, J.; Aramburu, L.; Vidal-Capon, A.; Villanueva, A.; Costas, D.; Rodriguez, R.; Prieto, T.; Tomas, L.; Alvarino, P.; Alonso, J.; Cao, A.S.C.; Iglesias, D.; Carballal, M.J.; Amaral, A.M.; Balseiro, P.; Calado, R.; El Khalfi, B.; Izagirre, U.; de Montaudouin, X.; Pade, N.G.; Probert, I.; Ricardo, F.; Ruiz, P.; Skazina, M.; Smolarz, K.; Pasantes, J.J.; Villalba, A.; Ning, Z.M.; Ju, Y.S.; Posada, D.; Demeulemeester, J.; Baez-Ortega, A.; Tubio, J.M.C. (2023). Somatic evolution of marine transmissible leukemias in the common cockle, Cerastoderma edule. Nature Cancer 4(11): 1575-1591. https://dx.doi.org/10.1038/s43018-023-00641-9
In: Nature Cancer. Nature Portfolio: Berlin. e-ISSN 2662-1347
Peer reviewed article  
Beschikbaar in  Auteurs 
Trefwoorden
    Cerastoderma edule (Linnaeus, 1758) [WoRMS]
    Marien/Kust
Auteurs  Top 
  • Bruzos, A.L.
  • Santamarina, M.
  • Garcia-Souto, D.
  • Diaz, S.
  • Rocha, S.
  • Zamora, J.
  • Lee, Y.A.
  • Vina-Feas, A.
  • Quail, M.A.
  • Otero, I.
  • Pequeno-Valtierra, A.
  • Temes, J.
  • Rodriguez-Castro, J.
  • Aramburu, L.
  • Vidal-Capon, A.
  • Villanueva, A.
  • Costas, D.
  • Rodriguez, R.
  • Prieto, T.
  • Tomas, L.
  • Alvarino, P.
  • Alonso, J.
  • Cao, A.S.C.
  • Iglesias, D.
  • Carballal, M.J.
  • Amaral, A.M.
  • Balseiro, P.
  • Calado, R.
  • El Khalfi, B.
  • Izagirre, U.
  • de Montaudouin, X.
  • Pade, N.G.
  • Probert, I.
  • Ricardo, F.
  • Ruiz, P.
  • Skazina, M.
  • Smolarz, K.
  • Pasantes, J.J.
  • Villalba, A.
  • Ning, Z.M.
  • Ju, Y.S.
  • Posada, D.
  • Demeulemeester, J.
  • Baez-Ortega, A.
  • Tubio, J.M.C.
Abstract
    Transmissible cancers are malignant cell lineages that spread clonally between individuals. Several such cancers, termed bivalve transmissible neoplasia (BTN), induce leukemia-like disease in marine bivalves. This is the case of BTN lineages affecting the common cockle, Cerastoderma edule, which inhabits the Atlantic coasts of Europe and northwest Africa. To investigate the evolution of cockle BTN, we collected 6,854 cockles, diagnosed 390 BTN tumors, generated a reference genome and assessed genomic variation across 61 tumors. Our analyses confirmed the existence of two BTN lineages with hemocytic origins. Mitochondrial variation revealed mitochondrial capture and host co-infection events. Mutational analyses identified lineage-specific signatures, one of which likely reflects DNA alkylation. Cytogenetic and copy number analyses uncovered pervasive genomic instability, with whole-genome duplication, oncogene amplification and alkylation-repair suppression as likely drivers. Satellite DNA distributions suggested ancient clonal origins. Our study illuminates long-term cancer evolution under the sea and reveals tolerance of extreme instability in neoplastic genomes.
Alle informatie in het Integrated Marine Information System (IMIS) valt onder het VLIZ Privacy beleid Top | Auteurs 
IMIS is ontwikkeld en wordt gehost door het VLIZ.