Zoeken
Zoeken kan via de modus 'eenvoudig zoeken' (één veld) of uitgebreid via 'geavanceerd zoeken' (meerdere velden). Zo kan je bv. zoeken op een combinatie van een auteursnaam (auteur), een jaartal (jaar) en een documenttype.
Boekenmand
Nuttige resultaten kan je aanvinken en toevoegen aan een mandje. De inhoud hiervan kan je exporteren of afdrukken (naar bv. PDF).
RSS
Op de hoogte blijven van nieuw toegevoegde publicaties binnen uw interessegebied? Dit kan door een RSS-feed (?) te maken van jouw zoekopdracht.
nieuwe zoekopdracht
Estrogenic effects in flounder Platichthys flesus orally exposed to 4-tert-octylphenol
In: Aquatic Toxicology. Elsevier Science: Tokyo; New York; London; Amsterdam. ISSN 0166-445X; e-ISSN 1879-1514
|  |
| Trefwoorden |
Diets
Secretory products > Hormones > Sex hormones
Vitellogenesis
Platichthys flesus (Linnaeus, 1758) [WoRMS]
Marien/Kust |
| Auteurs | | Top |
- Madsen, L.L., correspondent
- Korsgaard, B.
- Bjerregaard, P.
|
|
|
| Abstract |
The estrogenic effect of dietary 4-tert-octylphenol in the flounder Platichthys flesus was investigated in the laboratory. In the first experiment male flounders were fed doses of 10, 50 and 100 mg 4-tert-octylphenol kg-1 BW or 0.05 mg 17β-estradiol kg-1 BW every second day for 10 days. Increases in the plasma content of vitellogenin were observed on day 6 by the first sampling in all treated groups. An effect of octylphenol on the size of the liver and testis was only seen in one of the exposed group (50 mg 4-tert-octylphenol kg-1 BW). An increase in the concentration of 4-tert-octylphenol was found in both liver and muscle tissues of all 4-tert-octylphenol treated fish. The concentration of 4-tert-octylphenol (ng g-1+ WW) in liver tissue was four to five times greater than the concentration in muscle tissue. Only about 8% of the 4-tert-octylphenol administered to the group receiving 50 mg 4-tert-octylphenol kg-1 BW was retained in the liver and the muscles at the end of the experiment. In the second experiment male flounders were exposed to a low dose range of 4-tert-octylphenol (1 to 25 mg 4-tert-octylphenol kg-1 BW) in order to establish the dose-response relationship of 4-tert-octylphenol when applied by feeding to flounder. Vitellogenin induction (LOED) occurred at 10 and 5 mg 4-tert-octylphenol kg-1 BW after, respectively, 6 and 11 days of exposure. Based on a logistic regression analysis the effect dose (ED50 could be determined as 8.2 and 5.6 mg 4-tert-octylphenol kg-1 BW on day 6 and 11, respectively. 4-tert-octylphenol accumulated in liver, muscle and testis tissue, and a significant accumulation in liver was found at 2.5 mg 4-tert-octylphenol kg-1 BW and in muscle and testis at 5 mg 4-tert-octylphenol kg-1 BW. Finally, a positive correlation between the plasma vitellogenin concentration and the liver tissue concentration of 4-tert-octylphenol was established as well as a positive correlation between the content of 4-tert-octylphenol in liver and muscle/testis tissue. |
IMIS is ontwikkeld en wordt gehost door het VLIZ.
