Zoeken
Zoeken kan via de modus 'eenvoudig zoeken' (één veld) of uitgebreid via 'geavanceerd zoeken' (meerdere velden). Zo kan je bv. zoeken op een combinatie van een auteursnaam (auteur), een jaartal (jaar) en een documenttype.
Boekenmand
Nuttige resultaten kan je aanvinken en toevoegen aan een mandje. De inhoud hiervan kan je exporteren of afdrukken (naar bv. PDF).
RSS
Op de hoogte blijven van nieuw toegevoegde publicaties binnen uw interessegebied? Dit kan door een RSS-feed (?) te maken van jouw zoekopdracht.
| [ meld een fout in dit record ] | mandje (0): toevoegen | toon |
 |
| Genomic and ecological attributes of marine bacteriophages encoding bacterial virulence genes Silveira, C.B.; Coutinho, F.H.; Cavalcanti, G.S.; Benler, S.; Doane, M.P.; Dinsdale, E.A.; Edwards, R.A.; Francini-Filho, R.B.; Thompson, C.C.; Luque, A.; Rohwer, F.L.; Thompson, F. (2020). Genomic and ecological attributes of marine bacteriophages encoding bacterial virulence genes. BMC Genom. 21(1): 126. https://dx.doi.org/10.1186/s12864-020-6523-2
In: BMC Genomics. BioMed Central: London. e-ISSN 1471-2164
|   |
| Beschikbaar in | Auteurs |
| |
| Trefwoord |
|
| Author keywords |
|
| Auteurs | Top | |
|
|
|
| Abstract |
BackgroundBacteriophages encode genes that modify bacterial functions during infection. The acquisition of phage-encoded virulence genes is a major mechanism for the rise of bacterial pathogens. In coral reefs, high bacterial density and lysogeny has been proposed to exacerbate reef decline through the transfer of phage-encoded virulence genes. However, the functions and distribution of these genes in phage virions on the reef remain unknown. ResultsHere, over 28,000 assembled viral genomes from the free viral community in Atlantic and Pacific Ocean coral reefs were queried against a curated database of virulence genes. The diversity of virulence genes encoded in the viral genomes was tested for relationships with host taxonomy and bacterial density in the environment. These analyses showed that bacterial density predicted the profile of virulence genes encoded by phages. The Shannon diversity of virulence-encoding phages was negatively related with bacterial density, leading to dominance of fewer genes at high bacterial abundances. A statistical learning analysis showed that reefs with high microbial density were enriched in viruses encoding genes enabling bacterial recognition and invasion of metazoan epithelium. Over 60% of phages could not have their hosts identified due to limitations of host prediction tools; for those which hosts were identified, host taxonomy was not an indicator of the presence of virulence genes. ConclusionsThis study described bacterial virulence factors encoded in the genomes of bacteriophages at the community level. The results showed that the increase in microbial densities that occurs during coral reef degradation is associated with a change in the genomic repertoire of bacteriophages, specifically in the diversity and distribution of bacterial virulence genes. This suggests that phages are implicated in the rise of pathogens in disturbed marine ecosystems. |
| Top | Auteurs |
