Zoeken
Zoeken kan via de modus 'eenvoudig zoeken' (één veld) of uitgebreid via 'geavanceerd zoeken' (meerdere velden). Zo kan je bv. zoeken op een combinatie van een auteursnaam (auteur), een jaartal (jaar) en een documenttype.
Boekenmand
Nuttige resultaten kan je aanvinken en toevoegen aan een mandje. De inhoud hiervan kan je exporteren of afdrukken (naar bv. PDF).
RSS
Op de hoogte blijven van nieuw toegevoegde publicaties binnen uw interessegebied? Dit kan door een RSS-feed (?) te maken van jouw zoekopdracht.
nieuwe zoekopdracht
Anti-SARS-CoV-2 activity and cytotoxicity of Amaryllidaceae alkaloids from Hymenocallis littoralis
Le, N.T.H.; De Jonghe, S.; Erven, K.; Vermeyen, T.; Balde, A.M.; Herrebout, W.A.; Neyts, J.; Pannecouque, C.; Pieters, L.; Tuenter, E. (2023). Anti-SARS-CoV-2 activity and cytotoxicity of Amaryllidaceae alkaloids from Hymenocallis littoralis. Molecules 28(7): 3222. https://dx.doi.org/10.3390/molecules28073222
In: Molecules. MDPI: Basel. e-ISSN 1420-3049
|   |
| Trefwoord |
Angiosperms > Monocotyledons > Liliales > Amaryllidaceae > Hymenocallis > Antifungal plants > Ornamental bulbs > Antiviral plants > Hymenocallis littoralis
|
| Author keywords |
Amaryllidaceae alkaloids; Hymenocallis littoralis; lycorine-type; galanthamine-type; DFT calculation; SARS-CoV-2 |
| Auteurs | | Top |
- Le, N.T.H.
- De Jonghe, S.
- Erven, K.
- Vermeyen, T.
|
- Balde, A.M.
- Herrebout, W.A.
- Neyts, J.
|
- Pannecouque, C.
- Pieters, L.
- Tuenter, E.
|
| Abstract |
The Amaryllidaceae species are well-known as a rich source of bioactive compounds in nature. Although Hymenocallis littoralis has been studied for decades, its polar components were rarely explored. The current phytochemical investigation of Amaryllidaceae alkaloids from H. littoralis led to the identification of three previously undescribed compounds: O-demethyl-norlycoramine (1), (-)-2-epi-pseudolycorine (2) and (+)-2-epi-pseudolycorine (3), together with eight known compounds: 6 alpha-hydroxyhippeastidine (4), 6 beta-hydroxyhippeastidine (5), lycorine (6), 2-epi-lycorine (7), zephyranthine (8), ungeremine (9), pancratistatin (10) and 9-O-demethyl-7-O-methyllycorenine (11). Among the eight previously reported compounds, five were isolated from H. littoralis for the first time (compounds 4, 5, 7, 8, and 9). Compounds 1, 4, 5, 7, 8, and 11 exhibited weak anti-SARS-CoV-2 activity (EC50 = 40-77 mu M) at non-cytotoxic concentrations. Assessment of cytotoxicity on the Vero-E6 cell line revealed lycorine and pancratistatin as cytotoxic substances with CC50 values of 1.2 mu M and 0.13 mu M, respectively. The preliminary structure-activity relationship for the lycorine-type alkaloids in this study was further investigated, and as a result ring C appears to play a crucial role in their anti-SARS-CoV-2 activity. |
IMIS is ontwikkeld en wordt gehost door het VLIZ.
