Zoeken
Zoeken kan via de modus 'eenvoudig zoeken' (één veld) of uitgebreid via 'geavanceerd zoeken' (meerdere velden). Zo kan je bv. zoeken op een combinatie van een auteursnaam (auteur), een jaartal (jaar) en een documenttype.
Boekenmand
Nuttige resultaten kan je aanvinken en toevoegen aan een mandje. De inhoud hiervan kan je exporteren of afdrukken (naar bv. PDF).
RSS
Op de hoogte blijven van nieuw toegevoegde publicaties binnen uw interessegebied? Dit kan door een RSS-feed (?) te maken van jouw zoekopdracht.
nieuwe zoekopdracht
Exploring seasonal dynamics of sea spray aerosol bioactivity: Insights into molecular effects on human bronchial epithelial cells
Liu, Z.; Van Acker, E.; De Rijcke, M.; Van Nieuwerburgh, F.; Janssen, C.; Asselman, J. (2025). Exploring seasonal dynamics of sea spray aerosol bioactivity: Insights into molecular effects on human bronchial epithelial cells. Environ. Int. 195: 109255. https://dx.doi.org/10.1016/j.envint.2025.109255
In: Environment International. Pergamon: New York. ISSN 0160-4120; e-ISSN 1873-6750, meer
|   |
| Author keywords |
sea spray aerosol (SSA);Bronchial epithelial cells;RNA sequencing;Biogenics hypothesis;mTOR pathway;Seasonal variation;Oceans and human health;RED TIDE TOXINS;MARINE AEROSOL;HUMAN HEALTH;BLUE SPACES;EXPOSURE;ENRICHMENT;PARTICLES;COAST |
| Auteurs | | Top |
- Liu, Z.
- Van Acker, E.
- De Rijcke, M.
|
- Van Nieuwerburgh, F.
- Janssen, C.
- Asselman, J.
|
|
| Abstract |
Sea spray aerosol (SSA) is a complex mixture of natural substances that can be inhaled by coastal residents. Previous studies have suggested that SSA may have positive effects on human health, but the molecular mechanisms and the factors influencing these effects are poorly understood. In this study, we exposed human bronchial epithelial cells (BEAS-2B) to natural SSA samples, collected monthly using quartz microfiber filters mounted on tripods within 15 m of the waterline, with air drawn through pumps, throughout a one-year period at the Ostend coast, Belgium, and measured cellular gene expression changes using RNA sequencing. To simulate environmentally relevant exposure conditions, SSA extracts were applied at scaled doses equivalent to human alveolar exposure levels (multiplicative factors M = 10, 20, 40, and 80). We found that SSA exposure influenced the expression of genes involved in critical signaling pathways: mTOR, PI3K, Akt, and NF-kappa B were downregulated, while AMPK was upregulated. Downregulation of mTOR, PI3K, Akt, and NF-kappa B potentially indicates a protective response against tumor-promoting and inflammatory signals, whereas upregulation of AMPK may confer a beneficial effect on metabolic regulation. The number and direction of differentially expressed genes (DEGs) varied depending on the SSA sampling time and correlated with the phytoplankton density and chemical diversity of the SSA samples. Our results suggest that SSA contains bioactive compounds that may originate from marine algae and modulate cellular processes related to human health. We provide novel insights into the molecular effects of SSA exposure and highlight its potential as a source of natural therapeutics. To our knowledge, this is the first study to expose human lung cells to natural SSA at environmentally relevant levels, presenting a pioneering exploration of seasonal variations in exposure effects. |
IMIS is ontwikkeld en wordt gehost door het VLIZ.
