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Cadmium-induced changes in macromolecular synthesis at transcriptional and translational level in gill tissue of sea mussels, Mytilus edulis L.
Veldhuizen-Tsoerkan, M.B.; van der Mast, C.A.; Holwerda, D.A. (1992). Cadmium-induced changes in macromolecular synthesis at transcriptional and translational level in gill tissue of sea mussels, Mytilus edulis L. Comp. Biochem. Physiol. 103(2): 411-417. https://dx.doi.org/10.1016/0742-8413(92)90030-B
In: Comparative Biochemistry and Physiology. Pergamon Press: London; New York. ISSN 0010-406X
Peer reviewed article  
Beschikbaar in  Auteurs 
Trefwoorden
    Acids > Organic compounds > Organic acids > Nucleic acids > RNA
    Chemical compounds > Organic compounds > Proteins
    Chemical elements > Metals > Heavy metals > Cadmium
    Fauna > Aquatic organisms > Aquatic animals > Shellfish > Marine organisms > Marine molluscs
    Mytilus edulis Linnaeus, 1758 [WoRMS]
    Marien/Kust
Auteurs  Top 
  • Veldhuizen-Tsoerkan, M.B.
  • van der Mast, C.A.
  • Holwerda, D.A.
Abstract
    1. Sea mussels, Mytilus edulis, were exposed to cadmium chloride at 0–500 μg Cd/l for 48 hr. The gills were excised and incubated with protein and RNA precursors. The exposure resulted in a concentration-dependent inhibition of the synthesis of proteins and of RNA. The inhibitory effect was most pronounced in RNA synthesis.

    2. RNA was extracted from the gills as total RNA or as polyadenylated RNA. The translational activity of RNAs and the induction of mRNA for metallothionein-like proteins were studied by translation in a cell-free system.

    3. Exposure of the animals to cadmium at 500 μg/l caused a 5-fold increase in proto-oncogene c-fos mRNA.

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