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Estrogenicity of butylparaben in rainbow trout Oncorhynchus mykiss exposed via food and water
In: Aquatic Toxicology. Elsevier Science: Tokyo; New York; London; Amsterdam. ISSN 0166-445X; e-ISSN 1879-1514
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Vitellogenesis
Oncorhynchus mykiss (Walbaum, 1792) [WoRMS]
Zoet water |
| Auteurs | | Top |
- Alslev, B.
- Korsgaard, B.
- Bjerregaard, P.
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| Abstract |
The estrogenic effect of butylparaben was investigated in a rainbow trout Oncorhynchus mykiss test system. Butylparaben was administered orally to sexually immature rainbow trout every second day for up to 10 days in doses between 4 and 74mgkg(-1)2d(-1) and in the water at 35 and 201mugl(-1) for 12 days. Plasma vitellogenin was measured before and during the exposures and the concentrations of butylparaben in liver and muscle were determined at the end of experiments. Increases in average plasma vitellogenin levels were seen at oral exposure to 9mg butylparaben kg(-1)2d(-1). The ED(50) values for increase in vitellogenin synthesis were 46, 29 and 10.5mg butylparaben kg(-1)2d(-1), respectively, at day 3, 6 and 12. Exposure to 201mug butylparaben l(-1) increased vitellogenin synthesis, but exposure to 35mugl(-1) did not. Butylparaben showed little tendency to bioaccumulation in rainbow trout; less than 1 per thousand of the total amount of butylparaben administered orally at 51mgkg(-1)2d(-1) over the 12 days experimental period was retained in liver at the end of the experiment. After 12 days exposure to 35 and 201mug butylparaben l(-1), plasma concentrations were 9 and 183mugl(-1), respectively, and for the fish exposed to 201mugl(-1) there was a positive correlation between concentrations of vitellogenin and butylparaben in the plasma. On the assumption that butylparaben removed from the water phase during water exposure were taken up into the fish, butylparaben uptake rates in the fish exposed to 35 and 201mug butylparaben l(-1) were 13 and 78mgkg(-1)day(-1), respectively. |
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