Over het archief
Het OWA, het open archief van het Waterbouwkundig Laboratorium heeft tot doel alle vrij toegankelijke onderzoeksresultaten van dit instituut in digitale vorm aan te bieden. Op die manier wil het de zichtbaarheid, verspreiding en gebruik van deze onderzoeksresultaten, alsook de wetenschappelijke communicatie maximaal bevorderen.
Dit archief wordt uitgebouwd en beheerd volgens de principes van de Open Access Movement, en het daaruit ontstane Open Archives Initiative.
Basisinformatie over ‘Open Access to scholarly information'.
| [ meld een fout in dit record ] |
 |
| Mobilising the enzymatic potential of hydrocarbonoclastic bacteria and the oleaginous yeast Yarrowia lipolytica to create a powerful cellular production platform for lipidderived industrial materials | |
| www.lipoyeasts.ugent.be/ | |
|
Identifier financieringsorganisatie: FP7-KBBE-2007-1 (Other contract id) Acroniem: LIPOYEASTS Periode: Augustus 2008 tot Juli 2011 Status: Afgelopen |
|
| Instituten (7) | Top |
| |
| Abstract |
| This proposal aims at developing a versatile fermentation platform for the conversion of lipid feed stocks into diverse added-value products. It is proposed to develop the oleaginous yeast Yarrowia lipolytica into a microbial factory by directing its versatile lipid metabolism towards the production of industrially valuable compounds like wax esters (WE), polyhydroxyalkanoates (PHA’s), free hydroxyl fatty acids (HFA’s) and isoprenoid-derived compounds (carotenoids, polyenic carotenoid ester). Conversion of lipid intermediates into these products will be achieved by introducing heterologous
enzyme functions isolated from marine hydrocarbonoclastic bacteria into Yarrowia. To achieve these goals we have assembled a team with a broad set of complementary expertise in microbial physiology, metabolic engineering, yeast lipid metabolism, metagenomics, biochemical and protein engineering. Already available for this project are a number of genetically engineered Yarrowia strains as well as a collection of genes encoding enzymes for the production of WE’s, 3-HFA’s, PHA’s and carotenoids. The following complementary research focus areas are proposed: (1) Engineering of metabolic precursor pools in Yarrowia lipolytica for the production of added-value products from lipids (INRA, UGe). (2) Conversion of metabolic precursor pools in Yarrowia to added-value products by overexpressing heterologous biosynthetic enzymes (UGe, INRA, UoM). (3) Discovery and characterization of novel aliphatic enzyme activities by metagenomic screening of marine hydrocarbonoclastic and other oiland fat-metabolizing microbial communities (TUBS, UoN). The project is further complemented by: (i) the activity of a professional valorization company (Ascenion) providing IP protection and commercialization services; (ii) by proactive efforts to expand the project’s target products’ application potential (Avecom). |
| Top | Instituten |
