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Effects of seawater pollutants on protein tyrosine phosphorylation in mussel tissues Burlando, B.; Berti, E.; Viarengo, A. (2006). Effects of seawater pollutants on protein tyrosine phosphorylation in mussel tissues. Aquat. Toxicol. 78(Supplement 1): S79-S85. https://dx.doi.org/10.1016/j.aquatox.2006.02.020 In: Aquatic Toxicology. Elsevier Science: Tokyo; New York; London; Amsterdam. ISSN 0166-445X; e-ISSN 1879-1514, meer Ook verschenen in: Pampanin, D.M.; Anderson, O.K.; Viarengo, A. (Ed.) (2006). The Stavanger Workshop: Biological Effects of Environmental Pollution (BEEP) in marine coastal ecosystem: the Stavanger mesocosm exposure studies. Aquatic Toxicology, Special Issue 78(Suppl. 1). Elsevier: The Netherlands. S1-S128 pp., meer

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Beschikbaar in	Auteurs
VLIZ: Non-open access 284946 [ aanvragen ]

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Trefwoorden

Biomarkers Bisphenol A Oil Pollution > Water pollution > Marine pollution Water > Sea water ANE, Noordzee [Marine Regions] Marien/Kust

Author keywords

biomarkers; bisphenol A; blue mussel; diallyl phthalate; North Sea oil;PAH; seawater pollution; tetrabromodiphenylether-47

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Auteurs		Top
Burlando, B. Berti, E. Viarengo, A.

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Abstract

Different exogenous compounds are known to stimulate tyrosine kinase signaling, and this could explain a wide spectrum of pollutant effects on different organisms. We studied the effects of various seawater contaminants on tyrosine phosphorylation levels in different tissues of the mussel (Mytilus edulis), by using Western immunoblotting. Mussels were exposed in aquarium for 3 weeks to North Sea oil alone or to a mixture of North Sea oil, alkyl phenols, and polycyclic aromatic hydrocarbons (PAH). In another experiment, mussels were exposed for 3 weeks to each of the following potential endocrine disruptors: bisphenol A, diallyl phthalate, or tetrabromodiphenylether-47. In a third experiment, mussels were caged at four sites along a copper field gradient. Use of antiphosphotyrosine antibody showed that treatments with oil alone, or with oil, alkyl phenols and PAH induced phosphorylation increases in the digestive gland, gills and mantle. Bisphenol A produced significant effects in the gills and mantle, while diallyl phthalate and tetrabromodiphenylether-47 had a slight effect only on the gill tissue. Mussels exposed to the copper field gradient showed phosphotyrosine increases in the gills and mantle at intermediate levels of contamination. This latter result was also confirmed by using phosphospecific p38 antibody. In summary, the strength of induction was: oil mixture > oil > bisphenol A = copper; while the degree of tissue responsiveness was: mantle > gill > digestive gland. Based on these data, the use of tyrosine phosphorylation levels as a biomarker of seawater pollution is proposed.

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