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Het OWA, het open archief van het Waterbouwkundig Laboratorium heeft tot doel alle vrij toegankelijke onderzoeksresultaten van dit instituut in digitale vorm aan te bieden. Op die manier wil het de zichtbaarheid, verspreiding en gebruik van deze onderzoeksresultaten, alsook de wetenschappelijke communicatie maximaal bevorderen.

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Biological and chemical approaches for the detection and identification of illegal estrogens in water based solutions Noppe, H.; Arijs, K.; De Wasch, K.; Van Cruchten, S.; Poelmans, S.; Courtheyn, D.; Cobbaert, E.; Gillis, W.; Vanthemsche, P.; De Brabander, H.F.; Janssen, C.R.; Van Hoof, N. (2006). Biological and chemical approaches for the detection and identification of illegal estrogens in water based solutions, in: Noppe, H. Analytiek van hormoon verstorende stoffen in milieumatrices = Analytics of endocrine disrupting chemicals in environmental matrices. pp. 59-72 In: Noppe, H. (2006). Analytiek van hormoon verstorende stoffen in milieumatrices = Analytics of endocrine disrupting chemicals in environmental matrices. PhD Thesis. Universiteit Gent. Faculteit Diergeneeskunde: Gent. ISBN 978-90-5864-100-7. 153 pp., meer Is gerelateerd aan: Noppe, H.; Arijs, K.; De Wasch, K.; Van Cruchten, S.; Poelmans, S.; Courtheyn, D.; Cobbaert, E.; Gillis, W.; Vanthemsche, P.; De Brabander, H.F.; Janssen, C.R.; Van Hoof, N. (2006). Biological and chemical approaches for the detection and identification of illegal estrogens in water based solutions. Vet. Res. Comm. 30(6): 577-585. https://dx.doi.org/10.1007/s11259-006-3326-0, meer

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Beschikbaar in	Auteurs
VLIZ: Open Marine Archive 122325 [ download pdf ]

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Trefwoorden

Detection Estrogens Identification

Author keywords

animal trials; anatomy; GC-MSn; histology; LC-MSn; YES

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Endocrine disruption in the Scheldt Estuary: distribution, exposure and effects, meer

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Auteurs		Top
Noppe, H., meer Arijs, K., meer De Wasch, K., meer Van Cruchten, S.	Poelmans, S., meer Courtheyn, D. Cobbaert, E. Gillis, W.	Vanthemsche, P. De Brabander, H.F., meer Janssen, C.R., meer Van Hoof, N.

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Abstract

Continuous production of new products used as growth promotors in animal husbandry, sports doping and products for body-building, requires residue laboratories to initiate research on developing a strategy for the identification of ‘unknown’ components. In this study, a strategy for elucidating the identity, the structure and the possible effects of illegal estrogenic compounds in an unidentified water based solution is presented. To obtain complete information on the composition and activity of the unidentified product a multi-disciplinary approach was needed. A case-study is described with a ‘solution X’ found during a raid. At first, in vivo techniques (animal trials with mice, anatomical and histological research) were combined with in vitro techniques (the yeast estrogenic screen (YES)). In a later state of the investigation, HPLC fractionation, liquid chromatography-multiple mass spectrometry (LCMS- MS) and gas chromatography-multiple mass spectrometry (GC-MS-MS) were used. Finally, the identity of ‘solution X’ was confirmed in a low concentration range (10 ng.l-1 E1 and 400 ng.l-1 EE2).

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