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The sea anemone Bunodosoma granulifera contains surprisingly efficacious and potent insect-selective toxins Bosmans, F.; Aneiros, A.; Tytgat, J. (2002). The sea anemone Bunodosoma granulifera contains surprisingly efficacious and potent insect-selective toxins. FEBS Lett. 532(1-2): 131-134. dx.doi.org/10.1016/S0014-5793(02)03653-0 In: FEBS Letters. ELSEVIER SCIENCE BV: Amsterdam. ISSN 0014-5793; e-ISSN 1873-3468, meer

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Beschikbaar in	Auteurs
VLIZ: Open Marine Archive 133936 [ download pdf ]

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Trefwoorden

Amino acid sequence Aquatic organisms > Marine organisms > Aquatic animals > Marine invertebrates Bioactive compounds Biological phenomena > Evolution Biology > Physiology > Electrophysiology Cells > Sexual cells > Eggs > Oocytes Materials > Hazardous materials > Biological poisons Materials > Hazardous materials > Biological poisons > Neurotoxins Pesticides > Insecticides Toxins Bunodosoma granulifera (Le Sueur, 1817) [WoRMS]; Insecta [WoRMS] Marien/Kust

Author keywords

sea anemone toxin; voltage-gated sodium channel; neurotoxin;insecticide; evolution

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Auteurs		Top
Bosmans, F. Aneiros, A. Tytgat, J., meer

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Abstract

Two sodium channel toxins, BgII and BgIII, isolated from the sea anemone Bunodosoma granulifera, have been subjected to an elaborate electrophysiological and pharmacological comparison between five different cloned sodium channels expressed in Xenopus laevis oocytes in order to determine their efficacy, potency and selectivity. Our results reveal large differences in toxin-induced effect between the different sodium channels. These toxins possess the highest efficacy for the insect sodium channel (para). Our data also show that BgII, generally known as a neurotoxin, is especially potent on the insect sodium channel with an EC50 value of 5.5±0.5 nM. Therefore, this toxin can be used as a template for further development of new insecticides. Based on our findings, an evolutionary relationship between crustaceans and insects is also discussed.

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