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Testosterone metabolism in Neomysis integer following exposure to benzo(a)pyrene
Poelmans, S.; Verslycke, T.; Monteyne, E.; Noppe, H.; Verheyden, K.; Janssen, C.R.; De Brabander, H.F. (2006). Testosterone metabolism in Neomysis integer following exposure to benzo(a)pyrene. Comp. Biochem. Physiol. (B Biochem. Mol. Biol.) 144(4): 405-412. http://dx.doi.org/10.1016/j.cbpb.2006.04.001
In: Comparative Biochemistry and Physiology. Part B. Biochemistry and Molecular Biology. Pergamon: Oxford. ISSN 1096-4959; e-ISSN 1879-1107, meer
Peer reviewed article  
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Trefwoorden
    Biomarkers
    Cytochromes P450
    Metabolism
    Testosterone
    Neomysis integer (Leach, 1814) [WoRMS]
    Brak water; Zoet water
Auteurs  Top 
  • Verheyden, K.
  • Janssen, C.R., meer
  • De Brabander, H.F., meer
Abstract
    Cytochromes P450 (CYPs) are important enzymes involved in the regulation of hormone synthesis and in the detoxification and/or activation of xenobiotics. CYPs are found in virtually all organisms, from archae, and eubacteria to eukaryota. A number of endocrine disruptors are suspected of exerting their effects through disruption of normal CYP function. Consequently, alterations in steroid hormone metabolism through changes in CYP could provide an important tool to evaluate potential effects of endocrine disruptors. The aim of this study was to investigate the potential effects of the known CYP modulator, benzo(a)pyrene (B(a)P), on the testosterone metabolism in the invertebrate Neomysis integer (Crustacea; Mysidacea). N. integer were exposed for 96h to 0.43, 2.39, 28.83, 339.00 and 1682.86µg B(a)P L-1 and a solventcontrol, and subsequently their ability to metabolize testosterone was assessed. Identification and quantification of the produced phase I and phase II testosterone metabolites was performed using liquid chromatography coupled with multiple mass spectrometry (LC-MS2). Significant changes were observed in the overall ability of N. integer to metabolize testosterone when exposed to 2.39, 28.83, 339.00 and 1682.86µg B(a)P L-1 as compared to the control animals.
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