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Norchlorotestosterone acetate: an alternative metabolism study and GC-MS2 analysis in kidney fat, urine, and faeces
Van Hoof, N.; De Wash, K.; Poelmans, S.; Bruneel, D.; Spruyt, S.; Noppe, H.; Janssen, C.R.; Courtheyn, D.; De Brabander, H.F. (2004). Norchlorotestosterone acetate: an alternative metabolism study and GC-MS2 analysis in kidney fat, urine, and faeces. Chromatographia (Wiesb.) 59: S85-S93. https://dx.doi.org/10.1365/s10337-003-0178-4
In: Chromatographia. Vieweg Verlag: Heidelberg; Berlin. ISSN 0009-5893; e-ISSN 1612-1112, meer
Peer reviewed article  
Beschikbaar in  Auteurs 
Trefwoorden
    Analysis > Chemical analysis
    Analytical techniques > Chromatographic techniques > Gas chromatography
    Atmospheric pressure
    Chlorine organic compounds
    Electron impact
    Feces
    HPLC
    Kidneys
    Mass spectrometry
    Mass spectrometry
    Metabolism
    Metabolites
    Qualitative analysis
    Steroids
    Techniques > Methodology > Analytical methods > Spectroscopy > Spectrometry > Mass spectrometry
    Urine
    Arthropoda [WoRMS]; Crustacea [WoRMS]; Invertebrata [Ongewervelden]; Mysida [WoRMS]; Neomysis integer (Leach, 1814) [WoRMS]
    Zoet water
Auteurs  Top 
  • Van Hoof, N.
  • De Wash, K.
  • Poelmans, S., meer
  • Bruneel, D.
  • Spruyt, S.
  • Noppe, H., meer
  • Janssen, C.R., meer
  • Courtheyn, D.
  • De Brabander, H.F., meer
Abstract
    Norchlorotestosterone acetate (NCITA) is an anabolic steroid which resembles chlorotestosterone acetate. It cannot yet be detected by routine methods used for anabolic steroids, because there is no knowledge of its metabolic pathway. The invertebrate Neomysis integer has been used as an alternative model to study the metabolism of NCITA. The experimental results indicated the presence of 4-norchloroandrost-4-ene-17-ol-3-one (NCIT) and 4-norchloroand-rost-4-ene-3,17-dione (NorCIAD) as possible metabolites of NCITA. Subsequently NCITA and the synthesised metabolites NCIT and NorCIAD were incorporated into the routine multi-residue method for detection of anabolic steroids in kidney fat, urine, and faeces.
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