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Extending the record of bis-gamma-pyrone polypropionates from marine pulmonate mollusks
Carbone, M.; Ciavatta, M.L.; Wang, J.R.; Cirillo, I.; Mathieu, V.; Kiss, R.; Mollo, E.; Guo, Y.W.; Gavagnin, M. (2013). Extending the record of bis-gamma-pyrone polypropionates from marine pulmonate mollusks. J. Nat. Prod. 76(11): 2065-2073. https://dx.doi.org/10.1021/np400483c
In: Journal of Natural Products. American Chemical Society/American Society of Pharmacognosy: Washington DC. ISSN 0163-3864; e-ISSN 1520-6025, meer
Peer reviewed article  
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  • Carbone, M.
  • Ciavatta, M.L.
  • Wang, J.R.
  • Cirillo, I.
  • Mathieu, V., meer
  • Kiss, R., meer
  • Mollo, E.
  • Guo, Y.W.
  • Gavagnin, M.
Abstract
    The isolation and structure elucidation of 10 unreported polypropionate metabolites (compounds 6-15), structurally related to either ilikonapyrone (1) or onchidione (3), from two onchidiid pulmonate mollusk species are discussed. Structure elucidation was achieved by NMR spectroscopy and chemical correlation with model compounds. Evaluation of in vitro growth-inhibitory properties in human cancer cells was also carried out on some of the isolated polypropionates including previously reported onchidione metabolites.
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