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In vitro pharmacological and toxicological effects of Norterpene Peroxides isolated from the Red Sea sponge Diacarnus erythraeanus on normal and cancer cells
Lefranc, F.; Nuzzo, G; Hamdy, A; Fakhr, I; Banuls, L.M.Y.; Van Goietsenoven, G.; Villani, G; Mathieu, V.; van Soest, R; Kiss, R.; Ciavatta, L (2013). In vitro pharmacological and toxicological effects of Norterpene Peroxides isolated from the Red Sea sponge Diacarnus erythraeanus on normal and cancer cells. J. Nat. Prod. 76(9): 1541-1547. http://dx.doi.org/10.1021/np400107t
In: Journal of Natural Products. American Chemical Society/American Society of Pharmacognosy: Washington DC. ISSN 0163-3864; e-ISSN 1520-6025, meer
Peer reviewed article  
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Trefwoorden
    Diacarnus erythraeanus Kelly-Borges & Vacelet, 1995 [WoRMS]
    Marien/Kust
Auteurs  Top 
  • Lefranc, F.
  • Nuzzo, G
  • Hamdy, A
  • Fakhr, I
  • Banuls, L.M.Y.
  • Van Goietsenoven, G.
  • Villani, G
  • Mathieu, V., meer
  • van Soest, R
  • Kiss, R., meer
  • Ciavatta, L
Abstract
    Eight cyclic peroxide norterpenoids, compounds 1-8, have been isolated and characterized from the Red Sea sponge Diacarnus erythraeanus, including two new norsesterterpene derivatives (3, 4). Among these metabolites, (-)-muqubilin A (5) (nine cell lines analyzed) and the new compounds 3 and 4 (seven cell lines analyzed) displayed mean IC50 growth inhibitory concentrations in vitro of <10 mu M, while the remaining compounds (1, 6-8) were inactive in these cancer cell lines. Compound 5 displayed no selectivity between normal and cancer cells in terms of in vitro growth inhibition. Quantitative video microscopy analysis carried out on (-)-muqubilin A-treated cells validated the data obtained by means of the MTT colorimetric assay, while flow cytometry analysis revealed ROS production but no induction of apoptosis in cancer cells.
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