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Potential of Macrostomum lignano to recover from γ-ray irradiation De Mulder, K.; Kuales, G.; Pfister, D.; Egger, B.; Seppi, T.; Eichberger, P.; Borgonie, G.; Ladurner, P. (2010). Potential of Macrostomum lignano to recover from γ-ray irradiation. Cell Tissue Res. 339(3): 527-542. dx.doi.org/10.1007/s00441-009-0915-6 In: Cell and Tissue Research. Springer: Berlin; Heidelberg. ISSN 0302-766x; e-ISSN 1432-0878, meer

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Beschikbaar in	Auteurs
VLIZ: Open access 296042 [ download pdf ]

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Trefwoorden

Macrostomum lignano Ladurner, Schärer, Salvenmoser & Rieger, 2005 [WoRMS]; Planaria Müller, 1776 [WoRMS] Marien/Kust

Author keywords

Irradiation; Stem cells; Planaria; Flatworm; Macrostomum lignano(Platyhelminthes)

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De Mulder, K., meer Kuales, G. Pfister, D. Egger, B.	Seppi, T. Eichberger, P. Borgonie, G., meer Ladurner, P.

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Abstract

Stem cells are the only proliferating cells in flatworms and can be eliminated by irradiation with no damage to differentiated cells. We investigated the effect of fractionated irradiation schemes on Macrostomum lignano, namely, on survival, gene expression, morphology and regeneration. Proliferating cells were almost undetectable during the first week post-treatment. Cell proliferation and gene expression were restored within 1 month in a dose-dependent manner following exposure to up to 150 Gy irradiation. During recovery, stem cells did not cross the midline but were restricted within lateral compartments. An accumulated dose of 210 Gy resulted in a lethal phenotype. Our findings demonstrate that M. lignano represents a suitable model system for elucidating the effect of irradiation on the stem cell system in flatworms and for improving our understanding of the recovery potential of severely damaged stem-cell systems.

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