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Marine terpenoid diacylguanidines: structure, synthesis, and biological evaluation of naturally occurring actinofide and synthetic analogues
Carbone, M.; Ciavatta, M.L.; Mathieu, V.; Ingels, A.; Kiss, R.; Pascale, P.; Mono, E.; Ungur, N.; Guo, Y.-W.; Gavagnin, M. (2017). Marine terpenoid diacylguanidines: structure, synthesis, and biological evaluation of naturally occurring actinofide and synthetic analogues. J. Nat. Prod. 80(5): 1339-1346. https://dx.doi.org/10.1021/acs.jnatprod.6b00941
In: Journal of Natural Products. American Chemical Society/American Society of Pharmacognosy: Washington DC. ISSN 0163-3864; e-ISSN 1520-6025, meer
Peer reviewed article  
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Auteurs  Top 
  • Carbone, M.
  • Ciavatta, M.L.
  • Mathieu, V., meer
  • Ingels, A.
  • Kiss, R., meer
  • Pascale, P.
  • Mono, E.
  • Ungur, N.
  • Guo, Y.-W.
  • Gavagnin, M.
Abstract
    A new diacylguanidine, actinofide, has been isolated from the marine mollusk Actinocyclus papillatus. The structure, exhibiting a guanidine moiety acylated by two terpenoid acid units, has been established by spectroscopic methods and secured by synthesis. Following this, a series of structural analogues have been synthesized using the same procedure. All of the compounds have been evaluated in vitro for the growth inhibitory activity against a variety of cancer cell lines.
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