[ meld een fout in dit record ]mandje (0): toevoegen | toon Print deze pagina
Characterization of a tachykinin signalling system in the bivalve mollusc Crassostrea gigas
Dubos, M.-P.; Zels, S.; Schwartz, J.; Pasquier, J.; Schoofs, L.; Favrel, P. (2018). Characterization of a tachykinin signalling system in the bivalve mollusc Crassostrea gigas. Gen. Comp. Endocrinol. 266: 110-118. https://dx.doi.org/10.1016/j.ygcen.2018.05.003
In: General and Comparative Endocrinology. Elsevier: New York,. ISSN 0016-6480; e-ISSN 1095-6840, meer
Peer reviewed article  
Beschikbaar in  Auteurs 
Trefwoorden
    Mollusca [WoRMS]
    Marien/Kust
Author keywords
    Mollusc; Neuropeptide; Tachykinin signalling; Feeding
Auteurs  Top 
  • Dubos, M.-P.
  • Zels, S., meer
  • Schwartz, J.
  • Pasquier, J.
  • Schoofs, L., meer
  • Favrel, P.
Abstract
    Although tachykinin-like neuropeptides have been identified in molluscs more than two decades ago, knowledge on their function and signalling has so far remained largely elusive. We developed a cell-based assay to address the functionality of the tachykinin G-protein coupled receptor (Cragi-TKR) in the oyster Crassostrea gigas. The oyster tachykinin neuropeptides that are derived from the tachykinin precursor gene Cragi-TK activate the Cragi-TKR in nanomolar concentrations. Receptor activation is sensitive to Ala-substitution of critical Cragi-TK amino acid residues. The Cragi-TKR gene is expressed in a variety of tissues, albeit at higher levels in the visceral ganglia (VG) of the nervous system. Fluctuations of Cragi-TKR expression is in line with a role for TK signalling in C. gigas reproduction. The expression level of the Cragi-TK gene in the VG depends on the nutritional status of the oyster, suggesting a role for TK signalling in the complex regulation of feeding in C. gigas.
Alle informatie in het Integrated Marine Information System (IMIS) valt onder het VLIZ Privacy beleid Top | Auteurs 
IMIS is ontwikkeld en wordt gehost door het VLIZ.