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In vitro effect of copper ions on transbilayer distribution of aminophospholipids in synaptosomal membrane of walleye pollock (Theragra chalcogramma)
Kurilenko, A.V.; Zakhartsev, M.V.; Chelomin, V.P. (2002). In vitro effect of copper ions on transbilayer distribution of aminophospholipids in synaptosomal membrane of walleye pollock (Theragra chalcogramma). Aquat. Toxicol. 58(3-4): 131-136. dx.doi.org/10.1016/S0166-445X(01)00224-7
In: Aquatic Toxicology. Elsevier Science: Tokyo; New York; London; Amsterdam. ISSN 0166-445X; e-ISSN 1879-1514, meer
Peer reviewed article  
Beschikbaar in  Auteurs 
Trefwoorden
    Aquatic organisms > Marine organisms > Fish > Marine fish
    Chemical compounds > Organic compounds > Lipids
    Chemical compounds > Organic compounds > Lipids > Complex lipids
    Chemical elements > Metals > Transition elements > Heavy metals > Copper
    Chemical reactions > Redox reactions > Chemical reactions > Oxidation > Peroxidation > Lipid peroxidation
    Membranes
    Sulfhydryl groups
    Theragra chalcogramma (Pallas, 1814) [WoRMS]
    Marien/Kust
Author keywords
    copper; phosholipids; membrane asymmetry; sulfhydryl groups; lipid peroxidation; Theragra chalcogramma
Auteurs  Top 
  • Kurilenko, A.V.
  • Zakhartsev, M.V., meer
  • Chelomin, V.P.
Abstract
    Effect of copper ions on lipid matrix organization of synaptosomal membrane of the marine fish Theragra chalcogramma was investigated. It was demonstrated that interaction of copper ions with these membrane stimulated the process of lipid peroxidation and caused changes in the transbilayer distribution of aminophospholipids. Accessibility of phosphatidylethanolamine was increased more than twice, and of phosphatidylserine more than ten times, that can be explained by changes in asymmetrical structure of lipid matrix of synaptosomal membrane. We suggested, that the main mechanism of copper-stimulated damage in transbilayer organization of the membrane is oxidation of membrane protein sulfhydryl groups.
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