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The impact of mutations in the quorum sensing systems of Aeromonas hydrophila, Vibrio anguillarum and Vibrio harveyi on their virulence towards gnotobiotically cultured Artemia franciscana
Defoirdt, T.; Bossier, P.; Sorgeloos, P.; Verstraete, W. (2005). The impact of mutations in the quorum sensing systems of Aeromonas hydrophila, Vibrio anguillarum and Vibrio harveyi on their virulence towards gnotobiotically cultured Artemia franciscana. Environ. Microbiol. 7(8): 1239-1247. https://dx.doi.org/10.1111/j.1462-2920.2005.00807.x
In: Environmental Microbiology. Blackwell Scientific Publishers: Oxford. ISSN 1462-2912; e-ISSN 1462-2920, meer
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| Trefwoorden |
Aeromonas hydrophila; Artemia franciscana Kellog, 1906 [WoRMS]; Listonella anguillara (Bergeman, 1909) MacDonell & Colwell, 1985 [WoRMS]; Vibrio harveyi (Johnson & Shunk, 1936) Baumann & Baumann, 1981 [WoRMS]
Marien/Kust |
| Abstract |
Disruption of quorum sensing, bacterial cell-to-cell communication by means of small signal molecules, has been suggested as a new anti-infective strategy for aquaculture. However, data about the impact of quorum sensing on the virulence of aquatic pathogens are scarce. In this study, a model system using gnotobiotically cultured Artemia franciscana was developed in order to determine the impact of mutations in the quorum sensing systems ofAeromonas hydrophila, Vibrio anguillarum and V. harveyi on their virulence. Mutations in the autoinducer 2 (AI-2) synthase gene luxS, the AV. harvey abolished virulence of the strain towards Artemia. Moreover, the addition of an exogenous source of AI-2 could restore the virulence of an AI-2 non-producing mutant. In contrV. harveyi system or the quorum sensing systems of Ae. Hydrophila and V. anguillarum had an impact on virulence of these bacteria towards Artemia. Our results indicate that disruption of quorum sensing could be a good alternative strategy to combat infections caused by V. harvey. |
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