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Het OWA, het open archief van het Waterbouwkundig Laboratorium heeft tot doel alle vrij toegankelijke onderzoeksresultaten van dit instituut in digitale vorm aan te bieden. Op die manier wil het de zichtbaarheid, verspreiding en gebruik van deze onderzoeksresultaten, alsook de wetenschappelijke communicatie maximaal bevorderen.

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Neuro-apoptogenic and blood platelet targeting toxins in benthic marine cyanobacteria from the Portuguese coast Selheim, F.; Herfindal, L.; Martins, R.; Vasconcelos, V.; Døskeland, S.O. (2005). Neuro-apoptogenic and blood platelet targeting toxins in benthic marine cyanobacteria from the Portuguese coast. Aquat. Toxicol. 74(4): 294-306. https://dx.doi.org/10.1016/j.aquatox.2005.06.005 In: Aquatic Toxicology. Elsevier Science: Tokyo; New York; London; Amsterdam. ISSN 0166-445X; e-ISSN 1879-1514, meer

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Beschikbaar in	Auteurs
VLIZ: Non-open access 352519 [ aanvragen ]

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Trefwoorden

Blood platelets Aphanothece Nägeli, 1849 [WoRMS] ANE, Portugal [Marine Regions] Marien/Kust

Author keywords

blood platelets; toxic cyanobacteria; benthic cyanobacteria; Aphanothecesp.; neuroblastoma

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Auteurs		Top
Selheim, F. Herfindal, L. Martins, R.	Vasconcelos, V., meer Døskeland, S.O., correspondent

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Abstract

Six strains of marine cyanobacteria, of which five benthic, were isolated from an area of the Portuguese coast with no known apparent toxic microbial bloom. Five strains were lethal for mice. Four of them produced lethargy and four lead to bleeding. One of the toxic strains was from a genus (Aphanothece) not previously associated with toxin production. Extracts from four isolates induced SH-SY5Y-neuroblastoma cell apoptosis without affecting the viability of hepatocytes, NRK kidney cells, or fibroblasts. Aqueous extract from four isolates inhibited thrombin-induced blood platelet activation, with decreased P-selectin expression, platelet aggregation and shedding of platelet-derived micro-vesicles. Curiously, platelets treated with organic extracts from two of the cyanobacterial strains formed platelet micro-vesicles, expressed P-selectin on the surface and showed a distinct phosphotyrosine protein pattern, but failed to aggregate. We conclude that low-abundance marine cyanobacteria growing at low rates may be an important source for novel toxins that may be useful to dissect mammalian signalling pathways of apoptosis and platelet function.

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