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Het OWA, het open archief van het Waterbouwkundig Laboratorium heeft tot doel alle vrij toegankelijke onderzoeksresultaten van dit instituut in digitale vorm aan te bieden. Op die manier wil het de zichtbaarheid, verspreiding en gebruik van deze onderzoeksresultaten, alsook de wetenschappelijke communicatie maximaal bevorderen.

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Impairment of immune function in harbour seals (Phoca vitulina) feeding on fish from polluted waters de Swart, R.L.; Ross, P.S.; Vedder, L.J.; Timmerman, H.H.; Heisterkamp, S.H.; van Loveren, H.; Vos, J.G.; Reijnders, P.J.H.; Osterhaus, A.D.M.E. (1994). Impairment of immune function in harbour seals (Phoca vitulina) feeding on fish from polluted waters. Ambio 23: 155-159 In: Ambio. Royal Swedish Academy of Sciences: Oslo; Boston. ISSN 0044-7447; e-ISSN 1654-7209, meer Is gerelateerd aan: de Swart, R.L.; Ross, P.S.; Vedder, L.J.; Timmerman, H.H.; Heisterkamp, S.H.; van Loveren, H.; Vos, J.G.; Reijnders, P.J.H.; Osterhaus, A.D.M.E. (1995). Impairment of immune function in harbour seals (Phoca vitulina) feeding on fish from polluted waters, in: Ross, P.S. Seals, pollution and disease: environmental contaminant-induced immunosuppression = Zeehonden, vervuiling en infectieziekten: immuunsuppressie als gevolg van blootstelling aan milieuvervuilende stoffen. pp. 43-50, meer Is gerelateerd aan: de Swart, R.L.; Ross, P.S.; Vedder, L.J.; Timmerman, H.H.; Heisterkamp, S.H.; van Loveren, H.; Vos, J.G.; Reijnders, P.J.H.; Osterhaus, A.D.M.E. (1994). Impairment of immune function in harbour seals (Phoca vitulina) feeding on fish from polluted waters, in: de Swart, R.L. (1995). Impaired immunity in seals exposed to bioaccumulated environmental contaminants = Immuunsuppressie in zeehonden blootgesteld aan in de voedselketen geaccumuleerde milieuvervuilende stoffen. pp. 35-43, meer

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Trefwoorden

Aquatic organisms > Marine organisms > Aquatic mammals > Marine mammals Biological phenomena > Accumulation > Bioaccumulation Defence mechanisms Diseases Pollution effects Population functions > Mortality Properties > Biological properties > Biological resistance > Disease resistance Phoca vitulina Linnaeus, 1758 [WoRMS] Marien/Kust

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Auteurs		Top
de Swart, R.L. Ross, P.S. Vedder, L.J.	Timmerman, H.H. Heisterkamp, S.H. van Loveren, H.	Vos, J.G. Reijnders, P.J.H., meer Osterhaus, A.D.M.E.

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Abstract

Disease outbreaks with high mortality rates among seals and dolphins have recently attracted considerable public and scientific interest. Although in most cases morbillivirus infections were shown to be the primary cause of the disease outbreaks, it was speculated that pollution-induced immunosuppression had played a contributory role. Here we present results of a prospective study under semifield conditions, in which two groups of harbor seals (Phoca vitulina) were fed herring from marine regions with different contamination levels; the highly polluted Baltic Sea and the relatively unpolluted Atlantic Ocean. During a period of 93 weeks, parameters related to immune function were monitored and compared between the two groups. We found that natural killer-cell activity and mitogen-induced proliferative T-cell responses from the seals feeding on herring from the Baltic Sea were significantly lower. In addition, we observed higher levels of circulating polymorphonuclear granulocytes in these animals, which may indicate an increase in the occurrence of bacterial infections. This is the first demonstration of impaired immunological functions in mammals associated with chronic exposure to environmental contaminants accumulated through the marine food chain.

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