Open WL Archief (OWA)

Over het archief

Het OWA, het open archief van het Waterbouwkundig Laboratorium heeft tot doel alle vrij toegankelijke onderzoeksresultaten van dit instituut in digitale vorm aan te bieden. Op die manier wil het de zichtbaarheid, verspreiding en gebruik van deze onderzoeksresultaten, alsook de wetenschappelijke communicatie maximaal bevorderen.

Dit archief wordt uitgebouwd en beheerd volgens de principes van de Open Access Movement, en het daaruit ontstane Open Archives Initiative.

Basisinformatie over ‘Open Access to scholarly information'.

[ meld een fout in dit record ]

mandje (0): toevoegen | toon

---

Contaminant-related suppression of delayed-type hypersensitivity and antibody responses in harbour seals fed herring from the Baltic Sea Ross, P.S.; de Swart, R.L.; Reijnders, P.J.H.; van Loveren, H.; Vos, J.G.; Osterhaus, A.D.M.E. (1995). Contaminant-related suppression of delayed-type hypersensitivity and antibody responses in harbour seals fed herring from the Baltic Sea, in: de Swart, R.L. Impaired immunity in seals exposed to bioaccumulated environmental contaminants = Immuunsuppressie in zeehonden blootgesteld aan in de voedselketen geaccumuleerde milieuvervuilende stoffen. pp. 69-80 In: de Swart, R.L. (1995). Impaired immunity in seals exposed to bioaccumulated environmental contaminants = Immuunsuppressie in zeehonden blootgesteld aan in de voedselketen geaccumuleerde milieuvervuilende stoffen. PhD Thesis. Erasmus Universiteit Rotterdam: Rotterdam. ISBN 90-9008419-3. 140 pp., meer Is gerelateerd aan: Ross, P.S.; de Swart, R.L.; Reijnders, P.J.H.; van Loveren, H.; Vos, J.G.; Osterhaus, A.D.M.E. (1995). Contaminant-related suppression of delayed-type hypersensitivity and antibody responses in harbour seals fed herring from the Baltic Sea, in: Ross, P.S. Seals, pollution and disease: environmental contaminant-induced immunosuppression = Zeehonden, vervuiling en infectieziekten: immuunsuppressie als gevolg van blootstelling aan milieuvervuilende stoffen. pp. 81-91, meer Ross, P.S.; de Swart, R.L.; Reijnders, P.J.H.; van Loveren, H.; Vos, J.G.; Osterhaus, A.D.M.E. (1995). Contaminant-related suppression of delayed-type hypersensitivity and antibody responses in harbour seals fed herring from the Baltic Sea. Environ. Health Perspect. 103(2): 162-167. https://dx.doi.org/10.1289/ehp.95103162, meer

---

Beschikbaar in	Auteurs
VLIZ [ aanvragen ]

---

Trefwoorden

Fluids > Body fluids > Serum > Antibodies Immunity > Immune response > Immunity > Hypersensitivity Immunology Immunosuppression Pollution effects Therapy > Immunotherapy > Immunosuppression Toxicants Phoca vitulina Linnaeus, 1758 [WoRMS]; Phocidae Gray, 1821 [WoRMS] Marien/Kust

---

Auteurs		Top
Ross, P.S. de Swart, R.L. Reijnders, P.J.H., meer	van Loveren, H. Vos, J.G. Osterhaus, A.D.M.E.

---

Abstract

Recent mass mortalities among several marine mammal populations have led to speculation about increased susceptibility to viral infections as a result of contaminant-induced immunosuppression. In a 2.5-year study, we fed herring from either the relatively uncontaminated Atlantic Ocean or the contaminated Baltic Sea to two groups of captive harbor seals and monitored immune function in the seals. Seals fed the contaminated fish were less able to mount a specific immunological response to ovalbumin, as measured by in vivo delayed-type hypersensitivity (DTH) reactions and antibody responses. The skin reaction to this protein antigen was characterized by the appearance of mononuclear cells which peaked at 24 hr after intradermal administration, characteristic of DTH reactions in other animals studied. These DTH responses correlated well with in vitro tests of T-lymphocyte function, implicating this cell type in the reaction. Aryl-hydrocarbon (Ah) receptor-dependent toxic equivalent (TEQ) profiles in blubber biopsies taken from the seals implicated polychlorinated biphenyls rather than dioxins or furans in the observed immunosuppression. Marine mammal populations currently inhabiting polluted coastal environments in Europe and North America may therefore have an increased susceptibility to infections, and pollution may have played a role in recent virus-induced mass mortalities.

---

Alle informatie in het Integrated Marine Information System (IMIS) valt onder het VLIZ Privacy beleid

Top | Auteurs

IMIS is ontwikkeld en wordt gehost door het VLIZ.