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Het OWA, het open archief van het Waterbouwkundig Laboratorium heeft tot doel alle vrij toegankelijke onderzoeksresultaten van dit instituut in digitale vorm aan te bieden. Op die manier wil het de zichtbaarheid, verspreiding en gebruik van deze onderzoeksresultaten, alsook de wetenschappelijke communicatie maximaal bevorderen.
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Polychlorinated biphenyl (PCB)-contaminated fish induces vitamin A and thyroid hormone deficiency in the common seal (Phoca vitulina)
Brouwer, A.; Reijnders, P.J.H.; Koeman, J.H. (1989). Polychlorinated biphenyl (PCB)-contaminated fish induces vitamin A and thyroid hormone deficiency in the common seal (Phoca vitulina). Aquat. Toxicol. 15(1): 99-105. https://dx.doi.org/10.1016/0166-445X(89)90008-8
In: Aquatic Toxicology. Elsevier Science: Tokyo; New York; London; Amsterdam. ISSN 0166-445X; e-ISSN 1879-1514, meer
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Phoca vitulina Linnaeus, 1758 [WoRMS]
Marien/Kust |
| Auteurs | | Top |
- Brouwer, A.
- Reijnders, P.J.H., meer
- Koeman, J.H.
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| Abstract |
In this study the effect of polychlorinated biphenyl (PCB)-contaminated fish on plasma retinol (vitamin A) and thyroid hormone concentrations, i.e. sensitive indicators of PCB-intoxication, were investigated in the common seal Phoca vitulina. Seals fed fish from the Wadden Sea (high-level PCB contamination) had significantly lower concentrations of plasma retinol, total (TT4) and free thyroxin (FT4) and triiodothyronin (TT3) as compared to seals fed fish from the north-east Atlantic (low-level PCB contamination). The PCB-induced reduction in plasma retinol levels disappeared when seals on a Wadden Sea fish diet were subsequently fed Atlantic Ocean fish. It is suggested that reduced plasma retinol and thyroid hormone levels, which may result in an increased susceptibility to microbial infections, reproductive disorders and other pathological alterations, are critically involved in the recently reported reproductive disorders and the lethal viral infections in seals and other marine mammal populations in the Baltic, North Sea and Wadden Sea. |
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