Over het archief
Het OWA, het open archief van het Waterbouwkundig Laboratorium heeft tot doel alle vrij toegankelijke onderzoeksresultaten van dit instituut in digitale vorm aan te bieden. Op die manier wil het de zichtbaarheid, verspreiding en gebruik van deze onderzoeksresultaten, alsook de wetenschappelijke communicatie maximaal bevorderen.
Dit archief wordt uitgebouwd en beheerd volgens de principes van de Open Access Movement, en het daaruit ontstane Open Archives Initiative.
Basisinformatie over ‘Open Access to scholarly information'.
| one publication added to basket [21344] |
Modified absorption of sGNRH-a following rectal and oral delivery to common carp, Cyprinus carpio L.
Mikolajczyk, T.; Roelants, I.; Epler, P.; Ollevier, F.P.; Chyb, J.; Breton, B. (2002). Modified absorption of sGNRH-a following rectal and oral delivery to common carp, Cyprinus carpio L. Aquaculture 203(3-4): 375-388. dx.doi.org/10.1016/S0044-8486(01)00637-8
In: Aquaculture. Elsevier: Amsterdam; London; New York; Oxford; Tokyo. ISSN 0044-8486; e-ISSN 1873-5622, meer
|  |
| Trefwoord |
Cyprinus carpio Linnaeus, 1758 [WoRMS]
|
| Author keywords |
carp; gonadotropin releasing hormone analogue; dopamine antagonist; oral delivery; intestinal absorption enhancement; gonadotropin secretion |
| Auteurs | | Top |
- Mikolajczyk, T.
- Roelants, I.
- Epler, P.
|
- Ollevier, F.P., meer
- Chyb, J.
- Breton, B.
|
|
| Abstract |
The present study compare oral and rectal delivery routes of a salmonid gonadotropin releasing hormone analogue (sGnRH-a)+dopamine D2-receptor antagonist, pimozide (Pim), with parenteral administration. In addition, the effect of co-administration of absorption enhancers and peptidase inhibitors were evaluated. Responsiveness to the treatments was examined using GtH II release. Ten micrograms sGnRH-a and 5 mg/kg of Pim per kg fish bw were used in different formulations and routes of delivery. A mixed micellular intestinal absorption enhancement formulation, consisting of oleic acid and a polyoxyethylenesorbitan (Tween), strongly augmented GtH II release stimulated by sGnRH-a+Pim. GtH II release following treatment did not differ from that obtained after intraperitoneal injection of these drugs. In comparison with the saline control or with intraperitoneal injection, the oral and rectal administration of sGnRH a+Pim without intestinal absorption enhancement was not effective in stimulating GtH II release. The addition of the enzyme inhibitor, Na2EDTA or chicken egg trypsin inhibitor to this formulation was only moderately effective in increasing circulating GtH II levels. Among different Tweens, preformulated with oleic acid in a mixed micellular absorption enhancer for rectal delivery of sGnRH-a at a dose of 20 µg/kg bw in pimozide pretreated carps, Tween 20 and Tween 40, resulted in the highest systemic GtH II levels. |
IMIS is ontwikkeld en wordt gehost door het VLIZ.
